Can Automated Text Messaging Successfully Monitor Antibiotic Adherence for Urban Adolescents and Young Women Managed for Pelvic Inflammatory Disease in the Outpatient Setting

Authors

  • Bria Rice Department of Internal Medicine, Mayo Clinic, Phoenix, Arizona, USA
  • Jamie Perin Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
  • Steven Huettner Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
  • Arlene Butz Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
  • Hasiya E. Yusuf Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
  • Maria Trent Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA

DOI:

https://doi.org/10.17140/PNNOJ-8-135

Keywords:

Pelvic inflammatory disease, Sexually transmitted infections, Adolescents, Outpatient, Text messaging, Community health nursing

Abstract

Objective
This study evaluates patient responsiveness to an automated text messaging system for pelvic inflammatory disease (PID) self-care support, and measures the reliability of text-reported adherence.
Design
Patients aged 13-25-years with mild to moderate PID were recruited from urban, academic outpatient settings. Enrolled patients received antibiotics and were randomized into a standard of care or intervention group. During a 14-day treatment period, participants in the intervention arm received a community-based nursing visit and daily text message medication reminders with evening prompts to report the number of doses taken.
Result
Of the 97 participants randomized into the intervention arm, 91 (94%) were eligible for analysis. Most were African American and low income, with a mean age of 18.3 (SD=2.2) years. Participants responded to ~53% (SD=34%) of all dosage inquiry messages. Responsiveness attenuated at approximately 2.2% per day over the treatment period. Ninety-three percent (n=85) of the analyzed intervention arm returned for the two-week follow-up. Despite overall adherence and general responsiveness, text-reported and self-reported medication adherence were not well correlated (r=0.37, p<0.001).
Conclusion
Our findings show that text messaging is a feasible strategy for reaching urban adolescents being managed for complicated sexually transmitted infections in outpatient settings. However, patient responsiveness to self-care text messages do vary, limiting the adherence monitoring capacity of this technology. Given the number of unanswered text messages and incomplete text-reported adherence data, additional measures to assess adolescents’ adherence to PID medications are needed in clinical trials. 

References

Hay PE, Kerry SR, Normansell R, et al. Which sexually active young female students are most at risk of pelvic inflammatory dis-ease? A prospective study. Sex Transm Infect. 2016; 92(1): 63-66. doi: 10.1136/sextrans-2015-052063

Gradison M. Pelvic Inflammatory Disease. American Family Physi-cian. 2012: 85(8): 791-796.

Simms I, Stephenson JM, Mallinson H, et al. Risk factors as-Original Research | Volume 8 | Number 1| sociated with pelvic inflammatory disease. Sex Transm Infect. 2006; 82(6): 452-457. doi: 10.1136/sti.2005.019539

Goyal M, Hersh A, Luan X, Localio R, Trent M, Zaoutis T. Na-tional trends in pelvic inflammatory disease among adolescents in the emergency department. J Adolesc Health. 2013; 53(2): 249-252. doi: 10.1016/j.jadohealth.2013.03.016

Centers for Disease Control and Prevention (CDC). 2015 Sexu-ally Transmitted Diseases Surveillance: STD In Women and In-fants. http://medbox.iiab.me/modules/en-cdc/www.cdc.gov/ std/stats15/womenandinf.htm. Accessed December 12, 2016.

Gray-Swain MR, Peipert JF. Pelvic inflammatory disease in ado-lescents. Current Opinion Obstetrics & Gynecology. 2006; 18(5): 503- 510. doi: 10.1097/01.gco.0000242952.87125.69

Workowski KA, Bolan GA. Sexually transmitted disease treat-ment guidelines. Recommendations and Reports. 2015; 64(RR3): 1-137.

Rein DB, Kassler WJ, Irwin KL, Rabiee L. Direct medical cost of pelvic inflammatory disease and its sequelae: Decreasing, but still substantial. Obstet Gynecol. 2000; 95(3): 397-402. doi: 10.1016/ s0029-7844(99)00551-7

Trent M, Ellen JM, Frick KD. Estimating the direct costs of pelvic inflammatory disease in adolescents: A within-system analysis. Sex Transm Dis. 2011; 38(4): 326-328. doi: 10.1097/ OLQ.0b013e3181fc6c65

Ness RB, Trautmann G, Richter HE, et al. Effectiveness of treatment strategies of some women with pelvic inflammatory dis-ease: A randomized trial. Obstet Gynecol. 2005; 106(3): 573-580. doi: 10.1097/01.AOG.0000175193.37531.6e

Dunbar-Jacob J, Sereika SM, Foley SM, Bass DC, Ness RB. Adherence to oral therapies in pelvic inflammatory dis-ease. J Womens Health (Larchmt). 2004; 13(3): 285-291. doi: 10.1089/154099904323016446

Shafer MA, Sweet RL. Pelvic inflammatory disease in adoles-cent females. Adolesc Med. 1990; 1(3): 545-564.

Igra V. Pelvic Inflammatory disease in adolescents. AIDS Patient Care STDS. 1998; 12(2): 109-124. doi: 10.1089/apc.1998.12.109

Trent M, Judy SL, Ellen JM, Walker A. Use of an institu-tional intervention to improve quality of care for adolescents treated in pediatric ambulatory settings for pelvic inflammatory disease. J Adolesc Health. 2006; 39(1): 50-56. doi: 10.1016/j.jado-health.2005.08.008

Trent M, Chung SE, Burke M, Walker A, Ellen JM. Results of a randomized controlled trial of a brief behavioral intervention for pelvic inflammatory disease in adolescents. J Pediatr Adolesc Gynecol. 2010; 23(2): 96-101. doi: 10.1016/j.jpag.2009.06.005

Trent M, Bass D, Ness RB, Haggerty C. Recurrent PID, subse-Original Research | Volume 8 | Number 1| Trent M, et al quent STI, and reproductive health outcomes: Findings from the PID evaluation and clinical health (PEACH) study. Sex Transm Dis. 2011; 38(9): 879-881. doi: 10.1097/OLQ.0b013e31821f918c

Trent M, Chung SE, Forrest L, Ellen JM. Subsequent sexually transmitted infection after outpatient treatment of pelvic inflam-matory disease. Arch Pediatr Adolesc Med. 2008; 162(11): 1022-1025. doi: 10.1001/archpedi.162.11.1022

Trent M, Haggerty CL, Jennings JM, Lee S, Bass DC, Ness R. Adverse adolescent reproductive health outcomes after pelvic inflammatory disease. Arch Pediatr Adolesc Med. 2011; 165(1): 49-54. doi: 10.1001/archpediatrics.2010.256

O’Grady M. SMS Usage Remains Strong In The US: 6 Billion Text Messages Are Sent Each Day. SMS Usage Remains Strong In The US: 6 Billion Text Messages Are Sent Each Day. 2012. https://www. forrester.com/blogs/12-06-19-sms_usage_remains_strong_in_ the_us_6_billion_sms_messages_are_sent_each_day/. Accessed December 12, 2016.

Atun R, Sittampalam S. A review of the characteristics and benefits of SMS in delivering healthcare. the role of mobile phones in increasing accessibility and efficiency in healthcare. https:// www.scienceopen.com/document?vid=af6c3dc0-a04a-4052-abf5- 395f468dbdda. Accessed December 12, 2016.

Fjeldsoe BS, Marshall AL, Miller YD. Behavior change interven-tions delivered by mobile telephone short-message service. Am J Prev Med. 2009; 36(2): 165-173. doi: 10.1016/j.amepre.2008.09.040

Heron KE, Smyth JM. Ecological momentary interventions: Incorporating mobile technology into psychosocial and health be-haviour treatments. Br J Health Psychol. 2010; 15(Pt 1): 1-39. doi: 10.1348/135910709X466063

Lenhart A. Teens, Smart Phones & Texting. https://www. pewresearch.org/internet/2012/03/19/Teens-Smartphones-Tex-ting/. Accessed December 12, 2016.

Kohut A, Wilke R, Menasce Horowitz J, et al. Global Digital Communication: Texting, Social Networking Popular Worldwide. https://www.pewresearch.org/global/2011/12/20/Global-Dig-ital-Communication-Texting-Social-Networking-Popular-World-wide/. Accessed December 12, 2016.

Lenhart A, Ling R, Campbell S, Purcell K. Teens and Mobile Phones. https://www.pewresearch.org/internet/2010/04/20/ teens-and-mobile-phones/. Accessed December 10, 2016.

Smith A. How Americans Use Text Messaging. https://www. pewresearch.org/internet/2011/09/19/How-Americans-Use-Text-Messaging/. Accessed December 10, 2016.

Johnson SL, Tandon SD, Trent M, Jones V, Cheng TL. Use of technology with health care providers: Perspectives from ur-ban youth. J Pediatr. 2012; 160(6): 997-1002. doi: 10.1016/j. jpeds.2011.11.059

Irons M, Tomaszewski K, Muñoz Buchanan CR, Trent M. Un-derstanding adolescent non-responsiveness to text messages: Les-sons from the depotext trial. J Urban Health. 2015; 92(3): 502-512. doi: 10.1007/s11524-015-9950-7

Trent M, Thompson C, Tomaszewski K. Text messaging sup-port for urban adolescents and young adults using injectable con-traception: Outcomes of the depotext pilot trial. J Adolesc Health. 2015; 57(1): 100-106. doi: 10.1016/j.jadohealth.2015.03.008

Dowshen N, Kuhns LM, Johnson A, Holoyda BJ, Garofalo R. Improving adherence to antiretroviral therapy for youth living with HIV/AIDS: A pilot study using personalized, interactive, dai-ly text message reminders. J Med Internet Res. 2012; 14(2): e51. doi: 10.2196/jmir.2015

Dowshen N, Kuhns LM, Gray C, Lee S, Garofalo R. Feasibil-ity of interactive text message response (ITR) as a novel, real-time measure of adherence to antiretroviral therapy for HIV+ Youth. AIDS Behav. 2013; 17(6): 2237-2243. doi: 10.1007/s10461-013- 0464-6

Hall AK, Cole-Lewis H, Bernhardt JM. Mobile text mes-saging for health: A systematic review of reviews. Annu Rev Public Health. 2015; 36: 393-415. doi: 10.1146/annurev-publ-health-031914-122855

Wolff M, Balamuth F, Sampayo E, Mollen C. Improving ado-lescent pelvic inflammatory disease follow-up from the emergency department: Randomized controlled trial with text messages. Ann Emerg Med. 2016; 67(5): 602-609.e3. doi: 10.1016/j.annemerg-med.2015.10.022

Butz AM, Gaydos C, Chung S-E, Johnson BH, Huettner S, Trent M. Care-seeking behavior after notification among young women with recurrent sexually transmitted infections after pelvic inflammatory disease. Clin Pediatr (Phila). 2016; 55(12): 1107-1112. doi: 10.1177/0009922816662863

Trent M, Chung SE, Gaydos C, et al. Recruitment of minor-21 Trent M, et al ity adolescents and young adults into randomized clinical trials: Testing the design of the technology enhanced community health nursing (TECH-N) pelvic inflammatory disease trial. Eur Med J Re-prod Health. 2016; 2(1): 41-51.

Trent M, Perin J, Gaydos CA, et al. Efficacy of technolo-gy-enhanced community health nursing in females with PID. JAMA Netw Open. 2019; 2(8): e198652. doi: 10.1001/jamanet-workopen.2019.8652

Reify HEALTH. Better. Sooner. Together. Clinical research starts with diverse enrollment. http://www.reifyhealth.com. Ac-cessee December 12, 2016.

Cornelius JB, Dmochowski J, Boyer C, St Lawrence J, Lightfoot M, Moore M. Text-messaging-enhanced HIV intervention for afri-can american adolescents: A feasibility study. J Assoc Nurses AIDS Care. 2013; 24(3): 256-267. doi: 10.1016/j.jana.2012.06.005

Pop-Eleches C, Thirumurthy H, Habyarimana JP, et al. Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limiting setting: A randomized controlled trial of text message reminders. AIDS. 2011; 25(6): 825-834. doi: 10.1097/ QAD.0b013e32834380c1

Buchanan CM, Tomaszewski K, Chung S, Upadhya KK, Ramsey A, Trent ME. Why didn’t you text me? post-study trends from the depotext trial. Clinical Pediatrics. 2017; 57(1): 82-88. doi: 10.1177/0009922816689674

Stirratt MJ, Dunbar-Jacob J, Crane HM, et al. Self-report mea-sures of medication adherence behavior: Recommendations on optimal use. Transl Behav Med. 2015; 5(4): 470-82. doi: 10.1007/ s13142-015-0315-2

Ingersoll KS, Cohen J. The impact of medication regimen fac-tors on adherence to chronic treatment: A review of literature. J Behav Med. 2008; 31(3): 213-224.

Downloads

Published

2022-03-30

How to Cite

Bria Rice, Jamie Perin, Steven Huettner, Arlene Butz, Hasiya E. Yusuf, & Maria Trent. (2022). Can Automated Text Messaging Successfully Monitor Antibiotic Adherence for Urban Adolescents and Young Women Managed for Pelvic Inflammatory Disease in the Outpatient Setting. Pediatrics and Neonatal Nursing, 8(1), 14–24. https://doi.org/10.17140/PNNOJ-8-135