Recent Tendency of Therapeutic Medical Agents for Diabetic Peripheral Neuropathic Pain

Abstract

Recently, elder patients tend to have neuropathic pain such as lower back and joints pain, stiff shoulders, besides diabetic
neuropathy. Typical peripheral neuropathic pain includes diabetic peripheral neuropathic pain (DPNP), postherpetic neuralgia
(PHN) and chronic pain due to herniated disc. Three analgesic agents are described. Pregabalin (Lyrica®) has been prevalent
worldwide. However, it has been provided for several diseases for off-label administration, which has been one of the clinical
problems.Mirogabalin (Tarlige®) has revealed efficacy for DPNP in a dose-dependent manner. Duloxetine hydrochloride (Cymbalta
®) has efficacy for pain and also depression as serotonin and noradrenaline reuptake inhibitor (SNRI).