Dual Action Mechanism of Insulin Resistance and Insulin Secretion by Imeglimin for Diabetic Treatment
Keywords:
Imeglimin; Twymeeg; Trials of imeglimin for efficacy and safety 2 (TIMES 2), Glucose-stimulated insulin secretion (GSIS);, Transient receptor potential melastatin 2 (TRPM2) channel.Abstract
Imeglimin (Twymeeg) is novel oral hypoglycemic agent (OHA) developed in the glimin category. It has dual action mechanisms of
reducing insulin resistance and increasing insulin secretion. Trials of imeglimin for efficacy and safety 1 (TIMES 1), TIMES 2 and
TIMES 3 were performed with significant clinical efficacy. Among them, HbA1c decrease for 52 weeks showed single imeglimin
-0.46%, combined therapy of dipeptidyl peptidase-4i (DPP-4i)-0.92%, Glucagon-like peptide-1 receptor agonists (GLP-1RA)-0.12%
and insulin -0.63%. From physiological and pharmacological points of view, the mechanism may include the enhancement action
of glucose-stimulated insulin secretion (GSIS). For GSIS progress, transient receptor potential melastatin 2 (TRPM2) channel is
activated.
