Association of Pseudo-Meigs’ Syndrome with Struma Ovarii and High CA125 Mimicking Ovarian Malignancy
DOI:
https://doi.org/10.17140/GOROJ-2-113Keywords:
Pseudo-Meigs’ syndrome, Struma ovarii, Elevated CA-125, Ovarian malignancyAbstract
Pseudo-Meigs’ syndrome (PMS) is a rare condition in which a non-fibroma ovarian tumor, pleural effusion, and ascites coexist, and in which removal of the tumor resolves the condition. We present here a patient with struma ovarii-associated PMS, and with high serum CA-125 levels, bearing a resemblance to a malignant ovarian tumor. Arriving at an accurate diagnosis prior to surgery and before to receiving the final pathology report is very difficult to achieve. However, this association must be considered when pleural effusion is found, in addition to a heterogeneous pelvic mass with a rise in CA-125 is evident.
References
Obeidat BR, Amarin ZO. Struma ovarii with Pseudo-Meigs’ syndrome and elevated CA125 levels. J Obstet Gynaecol. 2007; 27(1): 97-98.
Rim SY, Kim SM, Choi HS. Struma ovarii showing clinical characteristics of ovarian malignancy. Int J Gynecol Cancer. 2005; 15(6): 1156-1159. doi: 10.1111/j.1525-1438.2005.00328.x
Loizzi V, Cormio G, Resta L, Fattizzi N, Vicino M, Selvag-gi L. Pseudo-Meigs syndrome and elevated CA125 associated with struma ovarii. Gynecol Oncol. 2005; 97(1): 282-284. doi: 10.1016/j.ygyno.2004.12.040
Mui MP, Tam K-F, Tam FKY, Ngan HYS. Coexistence of struma ovarii with marked ascites and elevated CA-125 levels: case report and literature review. Arch Gynecol Obstet. 2009; 279(5):753-757. doi: 10.1007/s00404-008-0794-1
Mitrou S, Manek S, Kehoe S. Cystic struma ovarii presenting as Pseudo-Meigs’ syndrome with elevated CA125 levels. A case report and review of the literature. Int J Gynecol Cancer. 2007; 18(2): 372-375. doi: 10.1111/j.1525-1438.2007.00998.x
Yücesoy G, Cakiroglu Y, Muezzinoglu B, Besnili B, Yucesoy I. Malignant struma ovarii: a case report. J Korean Med Sci. 2010; 25(2): 327-379. doi: 10.3346/jkms.2010.25.2.327
Paladini D, Vassallo M, Sglavo G, Nappi C. Struma ovarii associated with hyperthyroidism, elevated CA 125 and Pseudo-Meigs syndrome may mimic advanced ovarian cancer. Ultra-sound Obstet Gynecol. 2008; 32(2): 237-238. doi: 10.1002/ uog.5399
Huh JJ, Montz FJ, Bristow RE. Struma ovarii associated with Pseudo-Meigs’ syndrome and elevated serum CA 125. Gynecol Oncol. 2002; 86(2): 231-234. doi: 10.1006/gyno.2002.6741
Moran B, Baratti D, Yan TD, Kusamura S, Deraco M. Con-sensus statement on the loco-regional treatment of appendiceal mucinous neoplasms with peritoneal dissemination (pseudo-myxoma peritonei). J Surg Oncol. 2008; 98(4): 277-282. doi:
1002/jso.21054 10. Roth LM, Talerman A. The enigma of struma ovarii. Pathol-ogy. 2007; 39(1):139-146. doi: 10.1080/00313020601123979
Jin C, Dong R, Bu H, Yuan M, Zhang Y, Kong B. Coex-istence of benign struma ovarii, Pseudo-Meigs’ syndrome and elevated serum CA 125: Case report and review of the literature. Oncol Lett. 2015; 9(4): 1739-1742. doi: 10.3892/ol.2015.2927
Alvarado-luna G, Mora A, Mora A. Elevated CA125 level associated with Meigs’ syndrome : case report and review of the literature. 2006; 16: 315-318.
Wolff AL, Ladd AP, Kumar M, Gunderman RB, Stevens J. Pseudo-Meigs syndrome secondary to ovarian germ cell tu-mor. J Pediatr Surg. 2005; 40(4):737–9. doi: 10.1016/j.jped-surg.2005.01.016
Peparini N, Chirletti P. Ovarian malignancies with cyto-logically negative pleural and peritoneal effusions: demons’ or meigs’ pseudo-syndromes? Int J Surg Pathol. 2009: 396-397. doi: 10.1177/1066896909336441
Ural UM, Kiliç A, Güngör T, Ozdal B, Mollamahmutoğlu L. Tjalma’s or Pseudo-pseudo Meigs’ syndrome: a case report. Clin Exp Dermatol. 2008; 33(3): 363-364. doi: 10.1111/j.1365- 2230.2007.02665.x
Huang SE, Huang SC, Lee WY, Hsu K-F. Pseudo-Meigs’ syndrome caused by uterine smooth muscle tumor of uncertain malignant potential with low vascular endothelial growth fac-tor expression. Int J Gynecol Cancer. 2007; 18(4): 851-853. doi: 10.1111/j.1525-1438.2007.01115.x
Schmitt R, Weichert W, Schneider W, Luft FC, Kettritz R. Pseudo-pseudo Meigs’ syndrome. Lancet. 2005; 366(9497): 1672. doi: 10.1016/S0140-6736(05)67666-0
Hahm TS, Ham JS, Kang JY. Unilateral massive hydrotho-rax in a gynecologic patient with Pseudo-Meigs’ syndrome-a case report. Korean J Anesthesiol. 2010; 58(2): 202-206. doi: 10.4097/kjae.2010.58.2.202
Cheng M-H, Yen M-S, Chao K-C, Sheu B-C, Wang P-H. Differential diagnosis of gynecologic organ-related diseases in women presenting with ascites. Taiwan J Obstet Gynecol. 2008; 47(4): 384-390. doi: 10.1016/S1028-4559(09)60003-6
Sivrioglu AK, Saglam M, Sonmez G, Deveer M. Pseudo-Meigs’ syndrome associated with struma ovarii. BMJ Case Rep. 2013. doi: 10.1136/bcr-2013-009189
Peyron N, Coulon a. Struma ovarii, Pseudo-Meigs’syndrome and raised CA125, a rare association. Answer to May e-quid. Diagn Interv Imaging. 2012; 93(7-8): 643-647. doi: 10.1016/j. diii.2012.03.012
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in Gynecology and Obstetrics Research (GOR) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.
