Developmental Environmental Exposure Alters the Epigenetic Features of Myometrial Stem Cells
DOI:
https://doi.org/10.17140/GOROJ-3-e005Abstract
Uterine fibroids (UFs), are the most common pelvic tumors, occurring in 70-80% of all reproductive-aged women and are the leading indication for hysterectomy worldwide.1-3 Although UFs are benign tumors, they typically cause severe menstrual bleeding, pelvic pain, preterm labor, recurrent abortion, and infertility. Hysterectomy is currently the main treatment used in women who no longer desire childbearing.
References
Al-Hendy A, Salama S. Gene therapy and uterine leiomyoma: A review. Hum Reprod Update. 2006; 12(4): 385-400. doi: 10.1093/ humupd/dml015
Bulun SE. Uterine fibroids. N Engl J Med. 2013; 369: 1344-1355. doi: 10.1056/NEJMra1209993
Yang Q, Mas A, Diamond MP, Al-Hendy A. The mechanism and function of epigenetics in uterine leiomyoma development. Reprod Sci. 2016; 23(2): 163-175. doi: 10.1177/1933719115584449
Segars JH, Parrott EC, Nagel JD, et al. Proceedings from the Third National Institutes of Health International Congress on Ad-vances in Uterine Leiomyoma Research: Comprehensive review, conference summary and future recommendations. Hum Reprod Update. 2014; 20: 309-333. doi: 10.1093/humupd/dmt058
Sheiner E, Bashiri A, Levy A, Hershkovitz R, Katz M, Mazor M. Obstetric characteristics and perinatal outcome of pregnancies with uterine leiomyomas. J Reprod Med. 2004; 49(3): 182-186.
Hart R, Khalaf Y, Yeong CT, Seed P, Taylor A, Braude P. A prospective controlled study of the effect of intramural uterine fibroids on the outcome of assisted conception. Hum Reprod. 2001; 16(11): 2411-2417. doi: 10.1093/humrep/16.11.2411
Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: A review. Environ Health Perspect. 2003; 111(8): 1037-1054. Web site. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241553/. Accessed November 28, 2016.
Laughlin SK, Schroeder JC, Baird DD. New directions in the epidemiology of uterine fibroids. Semin Reprod Med. 2010; 28(3): 204-217. doi: 10.1055/s-0030-1251477
Grandjean P, Barouki R, Bellinger DC, et al. Life-Long implications of developmental exposure to environmental stressors: New perspectives. Endocrinology. 2015; 156: 3408-3415. doi: 10.1210/EN.2015-1350
Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986; 1: 1077-1081. doi: 10.1016/S0140-6736(86)91340-1
Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ. Developmental origins of non-communicable disease: Implica-tions for research and public health. Environmental Health: A Global Access Science Source. 2012; 11: 42. doi: 10.1186/1476-069X-11-42
Heindel JJ, Balbus J, Birnbaum L, et al. Developmental origins of health and disease: Integrating environmental influences. Endocrinology. 2015; 156(10): 3416-3421. doi: 10.1210/EN.2015-1394
Yang Q, Sun M, Ramchandran R, Raj JU. IGF-1 signaling in neonatal hypoxia-induced pulmonary hypertension: Role of epi-genetic regulation. Vascul Pharmacol. 2015; 73: 20-31. doi: 10.1016/j.vph.2015.04.005
Sun M, Ramchandran R, Chen J, Yang Q, Raj JU. Smooth muscle insulin-like growth factor-1 mediates hypoxia-induced pulmo-nary hypertension in neonatal mice. Am J Respir Cell Mol Biol. 2016. [In Press]. doi: 10.1165/rcmb.2015-0388OC
Yang Q, Diamond MP, Al-Hendy A. Early life adverse environmental exposures increase the risk of uterine fibroid development: Role of epigenetic regulation. Front Pharmacol. 2016; 7: 40. doi: 10.3389/fphar.2016.00040
Walker CL, Ho SM. Developmental reprogramming of cancer susceptibility. Nat Rev Cancer. 2012; 12(578): 479-486. doi: 10.1038/nrc3334
Katz TA, Yang Q, Trevino LS, Walker CL, Al-Hendy A. Endocrine-disrupting chemicals and uterine fibroids. Fertil Steril. 2016; 106: 967-977. doi: 10.1016/j.fertnstert.2016.08.023
Jorgensen EM, Alderman MH, 3rd, Taylor HS. Preferential epigenetic programming of estrogen response after in utero xenoes-trogen (bisphenol-A) exposure. FASEB J. 2016; 30(9): 3194-3201. doi: 10.1096/fj.201500089R
Gibson DA, Saunders PT. Endocrine disruption of oestrogen action and female reproductive tract cancers. Endocr Relat Cancer. 2014; 21: T13-T31. doi: 10.1530/ERC-13-0342
Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL. Xenoestrogen-induced regulation of EZH2 and his-tone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol. 2010; 24(5): 993-1006. doi: 10.1210/me.2009-0438
Greathouse KL, Bredfeldt T, Everitt JI, et al. Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis. Mol Cancer Res. 2012; 10(4): 546-557. doi: 10.1158/1541-7786.MCR-11-0605
Laiosa MD, Tate ER. Fetal hematopoietic stem cells are the canaries in the coal mine that portend later life immune deficiency. Endocrinology. 2015; 156: 3458-3465. doi: 10.1210/en.2015-1347
Ono M, Bulun SE, Maruyama T. Tissue-specific stem cells in the myometrium and tumor-initiating cells in leiomyoma. Biol Reprod. 2014; 91(6): 149. doi: 10.1095/biolreprod.114.123794
Walker CL, Hunter D, Everitt JI. Uterine leiomyoma in the Eker rat: A unique model for important diseases of women. Genes, Chromosomes Cancer. 2003; 38(4): 349-356. doi: 10.1002/gcc.10281
Mas A, Stone L, O’Connor PM, et al. Developmental exposure to endocrine disruptors expands murine myometrial stem cell compartment as a prerequisite to leiomyoma tumorigenesis. Stem Cells. 2016. [In Press]. doi: 10.1002/stem.2519
Prusinski L, Al-Hendy A, Yang Q. Developmental exposure to endocrine disrupting chemicals alters the epigenome: Identifica-tion of reprogrammed targets. Gynecol Obstet Res. 2016; 3(1): 1-6. doi: 10.17140/GOROJ-3-127
Wise LA, Palmer JR, Reich D, Cozier YC, Rosenberg L. Hair relaxer use and risk of uterine leiomyomata in African-American women. Am J Epidemiol. 2012; 175: 432-440. doi: 10.1093/aje/kwr351
D’Aloisio AA, Baird DD, DeRoo LA, Sandler DP. Association of intrauterine and early-life exposures with diagnosis of uterine leiomyomata by 35 years of age in the Sister Study. Environ Health Perspect. 2010; 118: 375-381. doi: 10.1289/ehp.0901423
Silbergeld EK, Patrick TE. Environmental exposures, toxicologic mechanisms, and adverse pregnancy outcomes. Am J Obstet Gynecol. 2005; 192: S11-S21. doi: 10.1016/j.ajog.2004.06.117
Weintraub M, Birnbaum LS. Catfish consumption as a contributor to elevated PCB levels in a non-Hispanic black subpopulation. Environ Res. 2008; 107(3): 412-417. doi: 10.1016/j.envres.2008.03.001
Meadows M. Heading off hair-care disasters. Use caution with relaxers and dyes. FDA Consumer. 2001; 35: 21-24. Web site. http://permanent.access.gpo.gov/lps1609/www.fda.gov/fdac/features/2001/101_hair.html. Accessed November 28, 2016.
Bulun SE, Moravek MB, Yin P, et al. Uterine leiomyoma stem cells: Linking progesterone to growth. Semin Reprod Med. 2015; 33(5): 357-365. doi: 10.1055/s-0035-1558451
Mas A, Nair S, Laknaur A, Simon C, Diamond MP, Al-Hendy A. Stro-1/CD44 as putative human myometrial and fibroid stem cell markers. Fertil Steril. 2015; 104(1): 225-234.e3. doi: 10.1016/j.fertnstert.2015.04.021
Yang Q, Trevino L, Mas A, et al. Early life developmental exposure to endocrine disrupting chemicals increases the risk of adult onset of uterine fibroids by permanently reprograming the epigenome of myometrial stem cells towards a pro-fibroid landscape. Fertil Steril. 2016; 106(3): e2. doi: 10.1016/j.fertnstert.2016.07.012
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