Impact of Resistance Training on Quality of Life and Ischemia Modified Albumin Levels in Men with Cardiovascular Risk Factors
DOI:
https://doi.org/10.17140/HROJ-1-103Keywords:
Quality of Life, Middle aged, Strength training, Health, Metabolic Syndrome X, Ischemia-modified serum albuminAbstract
Purpose: There are limited data concerning the effects of Resistance Training (RT) on the
components of Quality of Life (QOL) and Ischemia Modified Albumin (IMA) serum levels,
even though QOL is an important characteristic related to the treatment success involving non
communicable diseases. Studies regarding IMA and physical activity have focused only in the
acute effects of exercise. Thereby, the purpose of this study is to investigate the effects of a
moderate intensity RT on Health-related Quality of Life (HRQoL) and IMA levels in men with
cardiovascular risk factors.
Methods: Nineteen sedentary men (59 ± 8.63 years old) with metabolic syndrome (MS) components
underwent a RT with sessions three times a week, comprising 12 exercises, during 12
weeks. The Short-Form 36 was administered to evaluate the domains of physical and mental
components of HRQOL pre and post-intervention. Body composition and serum biochemical
parameters were analyzed.
Results: Volunteers had total body fat content and total muscle mass unchanged along the intervention.
With regard to serum analysis, triglycerides and IMA levels remained unchanged
with RT, while increased HDL levels (p < 0.001) and reduced ratio between total and HDL
cholesterol (p = 0.006) were observed. Moreover, improvements in the HRQOL subscales of
role-physical (p = 0.048), general health (p < 0.001), vitality (p < 0.001), social functioning (p
= 0.044) and mental health (p = 0.006) were verified after the RT.
Conclusions: It was concluded that a moderate RT is useful in providing benefits on quality of
life in men with cardiovascular risk factors, despite the maintenance of IMA levels.
References
Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the Internation-al Diabetes Federation Task Force on Epidemiology and Pre-vention. National Heart, Lung, and Blood Institute, American Heart Association, World Heart Federation, International Ath-erosclerosis Society and International Association for the Study of Obesity. Circulation. 2009;120(16):1640-1645. doi: 10.1161/ CIRCULATIONAHA.109.192644
Regitz-Zagrosek V, Lehmkuhl E, Weickert MO. Gender dif-ferences in the metabolic syndrome and their role for cardio-vascular disease. Clin Res Cardiol. 2006; 95(3): 136-1347. doi: 10.1007/s00392-006-0351-5
Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014; 384(9945):766- 781. doi: 10.1016/S0140-6736(14)60460-8
Stevens A, Schmidt MI, Duncan BB. Gender inequalities in non communicable disease mortality in Brazil. Cien Saude Colet. 2012; 17(10): 2627-2634. doi: http://dx.doi.org/10.1590/ S1413-81232012001000012
Kaefer M, Piva SJ, De Carvalho JA, et al. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clin Biochem. 2010; 43(4-5): 450-454. doi: 10.1016/j.clinbiochem.2009.11.018
van der Heijden MM, van Dooren FE, Pop VJ, Pouwer F. Effects of exercise training on quality of life, symptoms of de-pression, symptoms of anxiety and emotional well-being in type 2 diabetes mellitus: a systematic review. Diabetologia. 2013; 56(6): 1210-1225. doi: 10.1007/s00125-013-2871-7
Zhang X, Norris SL, Chowdhury FM, Gregg EW, Zhang P. The effects of interventions on health-related quality of life among persons with diabetes: a systematic review. Med Care. 2007; 45(9): 820-834. doi: 10.1097/MLR.0b013e3180618b55
Levinger I, Goodman C, Hare DL, Jerums G, Selig S. The ef-fect of resistance training on functional capacity and quality of life in individuals with high and low numbers of metabolic risk factors. Diabetes Care. 2007; 30(9): 2205-2210. doi: 10.2337/ dc07-0841
Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Schersten B, Agardh CD. Socio-demographic and psychosocial factors are as-sociated with features of the metabolic syndrome. The Women’s Health in the Lund Area (WHILA) study. Diabetes Obes Metab. 2003; 5(2): 106-112. doi: 10.1046/j.1463-1326.2003.00250.x
Ford ES, Li C. Metabolic syndrome and health-related qual-ity of life among U.S. adults. Ann Epidemiol. 2008; 18(3): 165- 171. doi: 10.1016/j.annepidem.2007.10.009
Williams MA, Haskell WL, Ades PA, et al. Resistance exer-cise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Associa-tion Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2007; 116(5): 572-584. doi: 10.1161/CIRCULATIONAHA.107.185214
Klimcakova E, Polak J, Moro C, et al. Dynamic strength training improves insulin sensitivity without altering plasma lev-els and gene expression of adipokines in subcutaneous adipose tissue in obese men. J Clin Endocrinol Metab. 2006; 91(12): 5107-5112. doi: http://dx.doi.org/10.1210/jc.2006-0382
Hurley BF, Hanson ED, Sheaff AK. Strength training as a countermeasure to aging muscle and chronic disease. Sports Med. 2011; 41(4): 289-306. doi: 10.2165/11585920-000000000- 00000
Guedes D, Guedes J. Manual prático para avaliação em edu-cação física. Barueri: Manole. 2006.
Bruce RA, Kusumi F, Hosmer D. Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am Heart J. 1973; 85(4): 546-562. doi: 10.1016/0002-8703(73)90502-4
Taguchi N, Higaki Y, Inoue S, Kimura H, Tanaka K. Effects of a 12-month multicomponent exercise program on physical performance, daily physical activity, and quality of life in very elderly people with minor disabilities: an intervention study. J Epidemiol. 2010; 20(1): 21-29. doi: http://dx.doi.org/10.2188/ jea.JE20081033
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18(6): 499-502.
Ciconelli R, Ferraz M, WWS, Meinão I, Quaresma R. Brazil-ian-portuguese version of SF-36: a reliable and valid quality of life outcome measure. Rev Bras Reumatol. 1999; 39: 143-150.
Garrat A, Schmidt L, Mackintosh A, Fitzpatrick R. Qual-ity of life measurement: bibliographic study of patient assessed health outcome measures. BMJ. 2002;15: 324(7351): 1417. doi:
Ware JE, Kosinski M. Interpreting SF-36 summary health measures: a response. Qual Life Res. 2001; 10(5): 405-413. doi: 10.1023/A:1012588218728
Plotnikoff RC, Eves N, Jung M, Sigal RJ, Padwal R, Kar-unamuni N. Multicomponent, home-based resistance training for obese adults with type 2 diabetes: a randomized controlled trial. Int J Obes (Lond). 2010; 34(12): 1733-1741. doi: 10.1038/ ijo.2010.109
Misra A, Alappan NK, Vikram NK, et al. Effect of super-vised progressive resistance-exercise training protocol on insu-lin sensitivity, glycemia, lipids, and body composition in Asian Indians with type 2 diabetes. Diabetes Care. 2008; 31(7): 1282- 1287. doi: 10.2337/dc07-2316
Berrougui H, Momo CN, Khalil A. Health benefits of high-density lipoproteins in preventing cardiovascular diseases. J Clin Lipidol. 2012; 6(6): 524-533. doi: 10.1016/j.jacl.2012.04.004
Duncan GE, Perri MG, Theriaque DW, Hutson AD, Eckel RH, Stacpoole PW. Exercise training, without weight loss, in-creases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care. 2003; 26(3): 557- 562. doi: 10.2337/diacare.26.3.557
Costa RR, Lima Alberton C, Tagliari M, Martins Kruel LF. Effects of resistance training on the lipid profile in obese wom-en. J Sports Med Phys Fitness. 2011; 51(1): 169-177.
Roy D, Quiles J, Sharma R, et al. Ischemia-modified albumin concentrations in patients with peripheral vascular disease and exercise-induced skeletal muscle ischemia. Clin Chem. 2004; 50(9):1656-1660. doi: 10.1373/clinchem.2004.031690
Middleton N, Shave R, George K, et al. Novel application of flow propagation velocity and ischaemia-modified albumin in analysis of postexercise cardiac function in man. Exp Physiol. 2006; 91(3): 511-519. doi: 10.1113/expphysiol.2005.032631
Apple FS, Quist HE, Otto AP, Mathews WE, Murakami MM. Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race. Clin Chem. 2002; 48(7): 1097-1100.
Falkensammer J, Stojakovic T, Huber K, et al. Serum levels of ischemia-modified albumin in healthy volunteers after exer-cise-induced calf-muscle ischemia. Clin Chem Lab Med. 2007; 45(4): 535-540. doi: 10.1515/CCLM.2007.087
Kurban S, Mehmetoglu I, Yerlikaya HF, Gonen S, Er-dem S. Effect of chronic regular exercise on serum isch-emia-modified albumin levels and oxidative stress in type 2 diabetes mellitus. Endocr Res. 2011; 36(3): 116-123. doi: 10.3109/07435800.2011.566236
Ul-Haq Z, Mackay DF, Fenwick E, Pell JP. Meta-analysis of the association between body mass index and health-related quality of life among adults, assessed by the SF-36. Obesity (Sil-ver Spring). 2013; 21(3): E322-E327. doi: 10.1002/oby.20107
Scott KM, Bruffaerts R, Simon GE, et al. Obesity and mental disorders in the general population: results from the world men-tal health surveys. Int J Obes (Lond). 2008; 32(1): 192-200. doi: 10.1038/sj.ijo.0803701
Rejeski WJ, Lang W, Neiberg RH, et al. Correlates of health-related quality of life in overweight and obese adults with type 2 diabetes. Obesity (Silver Spring). 2006; 14(5): 870-883. doi: 10.1038/oby.2006.101
Hakkinen A, Rinne M, Vasankari T, Santtila M, Hakkinen K, Kyrolainen H. Association of physical fitness with health-related quality of life in Finnish young men. Health Qual Life Outcomes. 2010; 8: 15. doi: 10.1186/1477-7525-8-15
Taspinar F, Aslanb UB, Agbugac B, Taspinara F. A com-parison of the effects of hatha yoga and resistance exercise on mental health and well-being in sedentary adults: A pilot study. Complement Ther Med. 2014; 22(3): 433-440. doi: 10.1016/j. ctim.2014.03.007
Singh NA, Clements KM, Fiatarone MA. A randomized controlled trial of progressive resistance training in depressed elders. J Gerontol A Biol Sci Med Sci. 1997; 52(1): M27-M35. doi: 10.1093/gerona/52A.1.M27
Hurley BF, Roth SM. Strength training in the elderly: effects on risk factors for age-related diseases. Sports Med. 2000; 30(4): 249-268. doi: 10.2165/00007256-200030040-00002
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