A Kinetic and Holistic Review of Iron and Copper Toxicity in Rat Liver

Authors

  • Rosario Musacco-Sebio Department of Analytical Chemistry and Physical Chemistry, General and Inorganic Chemistry Division, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
  • Christian Saporito-Magriñá Department of Analytical Chemistry and Physical Chemistry, General and Inorganic Chemistry Division, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
  • Juan M. Acosta Department of Analytical Chemistry and Physical Chemistry, General and Inorganic Chemistry Division, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
  • Alberto Boveris Department of Analytical Chemistry and Physical Chemistry, General and Inorganic Chemistry Division, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina; Institute of Biochemistry and Molecular Medicine (IBIMOL-CONICET), Buenos Aires, Argentina
  • Marisa G. Repetto Department of Analytical Chemistry and Physical Chemistry, General and Inorganic Chemistry Division, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina; Institute of Biochemistry and Molecular Medicine (IBIMOL-CONICET), Buenos Aires, Argentina

Keywords:

GSH, Reduced glutathione, SOD1, Cu, Zn-superoxide dismutase, GPx, Glutathione peroxidase, Nrf2, Nuclear factor erythroid 2-related factor 2

Abstract

Iron (Fe) and copper (Cu) overloads in rats showed a dose and time dependent metal accumulation in liver with its associated toxicity. The increased contents of the transition metals markedly enhanced the endogenous free-radical mediated processes of phospholipid peroxidation. In vivo liver chemiluminescence showed an increased production of 1O2, and a consumption of reduced glutathione (GSH), the main intracellular antioxidant. Results fit with a Haber-Weiss type molecular mechanism in which Fe or Cu and endogenously produced O2- and H2O2, yield HO• that initiates free-radical mediated phospholipid peroxidation and protein oxidation.

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Published

2024-05-10

How to Cite

Rosario Musacco-Sebio, Christian Saporito-Magriñá, Juan M. Acosta, Alberto Boveris, & Marisa G. Repetto. (2024). A Kinetic and Holistic Review of Iron and Copper Toxicity in Rat Liver. Liver Research, 5(1), 31–35. Retrieved from https://openventio.us/index.php/LROJ/article/view/1038

Issue

Vol. 5 No. 1 (2024): Volume 5 Issue 1 2024

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Articles

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