Impact of a “Golden Hour” Educational Intervention on Knowledge, Attitudes, and Practices Among Nursing Staff in Pediatric Emergency Departments Caring for Patients with Acute Lymphoblastic Leukemia

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Authors

DOI:

https://doi.org/10.17140/phoj-11-774

Keywords:

Educational intervention, Golden Hour, Febrile Neutropenia, Pediatric patients with ALL.

Abstract

The “golden hour” is an international protocol, spearheaded by St. Jude Children’s Research Hospital, for the management of pediatric cancer patients (ALL). Objective: To evaluate the impact of an educational intervention on nursing staff regarding the implementation of the “golden hour” protocol for patients with acute lymphoblastic leukemia (ALL). Methodology: A quasi-experimental study was conducted based on a quality improvement model that employs a collaborative approach and continuous improvement methodology. The study was carried out in emergency departments at various hospitals among 110 nurses working different shifts and was conducted in three phases:Phase I: adaptation and validation of the measurement instrument to assess participants’ knowledge level before the educational intervention; Phase II: design and implementation of a training program through theoretical and practical sessions on the “Golden Hour” protocol; and Phase III: assessment of participants’ knowledge before and after training and evaluation of the educational program’s impact. Descriptive and comparative statistical analysis was performed using SPSS version 30.0. Results: Before the educational intervention, 71% of participants were at the low level, 25% at the medium level, and 4% at the high level. Following the educational intervention, the high level reached 89%, the medium level decreased to 5%, and the low level to 1%. Conclusions: Following the implementation of the educational intervention, a significant improvement was observed in knowledge, attitude, and practice regarding the “golden hour” protocol in the care of pediatric patients with Acute Lymphoblastic Leukemia (ALL). There was a significant increase in understanding of key timeframes, warning signs, and essential therapeutic measures during the first hour of care, as well as a greater ability to prioritize key interventions, such as the timely administration of antibiotics, monitoring of vital signs, and identification of early complications, such as septic shock.

References

Quiroga López IB, Ruiz Reyes D, García Rodríguez D, Águila Carbelo M, Herrero Díaz A. Acute lym-phoblastic leukaemia in children. Nursing Depths Series [Internet]. 2025;5:301. Disponible en: http: //dx.doi.org/10.56294/nds2026301

Fonseca-Sepúlveda EV, Imbachi-Yunda LF, Camacho-Moreno G, Márquez-Herrera KC, Pardo-González CA, Linares-Ballesteros A. Clinical and microbiological characterization of pediatric patients with acute lymphoblastic leukemia presenting with febrile neutropenia. Infectio [Internet]. 2025;203–7. Disponible en: h t tp : //dx.doi.org/10.22354/24223794.1247

Rojas Soto N, Moreno Larrea M, Pizarro Perea M, Aranda Gomero L, Arteta Altamirano C, Eyza-guirre Zapata R, et al. Guía de Práctica Clínica para el manejo de pacientes con Leucemia Lin-foblástica Aguda en el Seguro Social del Perú (Es-Salud). Acta médica peru [Internet]. 2021;38(1):64– 78. Disponible en: http://dx.doi.org/10.35 663/amp.2021.381.1038

Gobierno del Estado de Baja California [Internet]. Gob.mx. Disponible en: https://appsweb.ebaj acalifornia.gob.mx/SAPG/api/ApiAdmon/N oticiaCompleta?NoticiaId=4690

Iniciativa Mundial contra el Cáncer Infantil de la OMS [Internet]. St. Jude Global Alliance. Disponible en: https://global.stjude.org/ es-us/about/collaborations/world-healt h-organization/global-initiative.html

St. Jude Children’s Research Hospital. Golden Hour Initiative for pediatric oncology patients [In-ternet]. Memphis: St. Jude; 2024. Disponible en: https://www.stjude.org/research/progre ss/2023/in-the-golden-hour-antibiotics -save-lives-in-latin-america.html

Emadi A, Law JY. Leucemia linfoblástica aguda (LLA) [Internet]. Manual MSD versión para profe-sionales. Manuales MSD; 2023. Disponible en: ht tps://www.msdmanuals.com/es-mx/profes sional/hematologÃŋa-y-oncologÃŋa/leuce mias/leucemia-linfoblÃąstica-aguda-lla

Solera-Gómez S, Benedito-Monleón A, LLinares-Insa LI, Sancho-Cantus D, Navarro-Illana E. Educational needs in oncology nursing: A scoping review. Healthcare (Basel) [Internet]. 2022;10(12):2494. Disponible en: http://dx.d oi.org/10.3390/healthcare10122494

Silva ES da, Primo CC, Gimbel S, Almeida MV de S, Oliveira NS, Lima E de FA. Elaboration and im-plementation of a protocol for the Golden Hour of premature newborns using an Implementation Science lens. Rev Lat Am Enfermagem [Internet]. 2023;31:e3956. Disponible en: http://dx.doi.o rg/10.1590/1518-8345.6627.3956

Wiedower L. In the ‘Golden Hour,’ antibiotics save lives in Latin America [Internet]. St. Jude Research. 2023. Disponible en: https://www.stjude.org /research/progress/2023/in-the-golde n-hour-antibiotics-save-lives-in-latin -america.html

Gonzalez ML, Aristizabal P, Loera-Reyna A, Torres D, Ornelas-Sánchez M, Nuño-Vázquez L, et al. The golden hour: Sustainability and clinical outcomes of adequate time to antibiotic administration in children with cancer and febrile neutropenia in northwestern Mexico. JCO Glob Oncol [Internet]. 2021;7(7):659–70. Available in: http://dx.doi .org/10.1200/GO.20.00578

Idyatul Hasanah, Nursalam Nursalam, Ilya Kris-nana, Wawan F. Ramdani, Zikrul Haikal, Tita Ro-hita. Psychoneuroimmunological Markers of Psy-chological Intervention in Pediatric Cancer: A Sys-tematic Review and New Integrative Model. Asian Nursing Research. 2023;17:119e137. Available in: https://doi.org/10.1016/j.anr.2023.07.

Colunga-Pedraza JE, Lopez-Reyna IG, Vaquera-Aparicio DN, Peña-Lozano SP, Arrieta J, Hernández-Torres LE, et al. Overcoming challenges to reduce time to antibiotic therapy in febrile neutropenic children: insights from a Mexican center. Hematol Transfus Cell Ther [Internet]. 2024;46 Suppl 6:S193–201. Disponible en: http://dx.doi.org/10.1016/j.htct.20 24.04.123

Gonzalez ML, Aristizabal P, Loera-Reyna A, Torres D, Ornelas-Sánchez M, Nuño-Vázquez L, et al. The golden hour: Sustainability and clinical outcomes of adequate time to antibiotic administration in children with cancer and febrile neutropenia in northwestern Mexico. JCO Glob Oncol [Internet]. 2021;7(7):659–70. Available in: http://dx.doi .org/10.1200/GO.20.00578

Sapri ND, Ng YT, Wu VX, Klainin-Yobas P. Effective-ness of educational interventions on evidence-based practice for nurses in clinical settings: A systematic review and meta-analysis. Nurse Educ Today [Internet]. 2022;111(105295):105295. Disponible en: http://dx.doi.org/10.1016/j .nedt.2022.105295

Alrashdi MH, Quinn B, Clarke SA. Barriers and fa-cilitators in implementing clinical practice guide-lines among nurses in emergency departments and critical care units: A systematic review. J Clin Nurs [Internet]. 2026;35(3):1060–78. Disponible en: http://dx.doi.org/10.1111/jocn.7008

Idyatul Hasanah, Nursalam Nursalam, Ilya Kris-nana, Wawan F. Ramdani, Zikrul Haikal, Tita Ro-hita. Psychoneuroimmunological Markers of Psy-chological Intervention in Pediatric Cancer: A Sys-tematic Review and New Integrative Model. Asian Nursing Research. 2023;17:119e137. Available in: https://doi.org/10.1016/j.anr.2023.07.

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Published

2026-07-26

How to Cite

Briseida Sarai Xalamihua Serrano, Claudia Izbeth Dimas Reséndiz, Olga Rocío Flores Chávez, María del Carmen López Zermeño, Leticia Carolina Hernández Esparza, Jesús Carlos Ruvalcaba Ledezma, … Josefina Reynoso Vázquez. (2026). Impact of a “Golden Hour” Educational Intervention on Knowledge, Attitudes, and Practices Among Nursing Staff in Pediatric Emergency Departments Caring for Patients with Acute Lymphoblastic Leukemia. Public Health - Open Journal, 11(1), 782. https://doi.org/10.17140/phoj-11-774