Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine
DOI:
https://doi.org/10.17140/TFMOJ-1-107Keywords:
Lambda cyhalothrin, Taurine, Wistar rat, Hepatic and gonadal toxicity, Lipid metabolismAbstract
Extensive application of pesticides is usually accompanied with serious problems of pollution and health hazards. Lambda-cyhalothrin (LCT), a type II synthetic pyrethroid, is widely used in agriculture, home pest control and protection of foodstuff. This study designed to evaluate the dose dependent haematological, hepatic and gonadal toxicity of LCT at different dose levels in Wistar rat. Investigations were also done to find out the toxic effect of lambda cyhalothrin on lipid metabolism in female rat and its amelioration by taurine. Rats were exposed to different doses of lambda cyhalothrin over a period of 14 consecutive days. Exposure to LCT produced ataxia, agitation, rolling and also tremors which were considered as the signs of toxicity. Significant decrease in erythrocyte count, haemoglobin percentage, seminal fructose concentration, hepatic and testicular reduced glutathione (GSH) content was observed.
Increase in leukocyte count, serum aspartic and alanine transaminase, hepatic and testicular malondialdehyde (MDA), testicular and ovarian cholesterol after LCT treatment were seen in male rats at the dose level of 10.83 mg/kg body wt. (1/7th LD50). Elevated ovarian cholesterol and MDA and reduced 3β hydroxy steroid dehydrogenase (HSD) and GSH level were also observed in lambda cyhalothrin exposed female rat at the dose level of 6.29 mg/kg body wt. (1/9th LD50). LCT caused increase in serum triglyceride, cholesterol, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and bilirubin and decrease in serum high density lipoproteins (HDL) in female rat. Taurine pretreatment ameliorated LCT induced altered lipid metabolic biomarkers in female rat.
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