Reducing the Effect of Taurine on Oxidative Stress and Renal Lipid Peroxidation in Rats Exposed to Lambda-Cyhalothrin
Keywords:
Lambda-cyhalothrin, Taurine, Renal index, Renal toxicity, Oxidative stressAbstract
Background
Lambda-cyhalothrin (LCT) is an isomeric form of the two biologically active diastereoisomeric pairs of cyhalothrin, containing an alpha-cyano group. Taurine or 2-aminoethane sulfonic acid is a sulfur-containing α-amino acid that is the most abundant free amino acid in most mammal tissue.
Aim and Objectives
The present study was focused to investigate lambda-cyhalothrin induced nephrotoxicity and renal oxidative stress as well as to evaluate the alleviating role of taurine in this condition.
Methods
Lambda-cyhalothrin was administered orally at two dose levels (10.83 and 15.17 mg/kg body weight) alone or in combination after pre-treatment of taurine (50 mg/kg body weight) for consecutive 14 days.
Results
Renal toxicity was measured by a significant decrease in renal index, reduction in kidney protein and an increase in serum protein in lambda-cyhalothrin intoxicated rats. At the same time, lambda-cyhalothrin induced a significant renal oxidative stress demon strated by elevated renal malondialdehyde content and oxidized glutathione level accompanied by a reduction in reduced glutathione and antioxidant enzymes in rats. Lambda-cyhalothrin induced renal toxicity and oxidative stress in the rat was significantly ameliorated due to the administration of taurine as an antidote.
Conclusion
All of these findings of the present study strongly suggest the protective role of taurine in the pathophysiology of lambda-cyhalothrin-induced renal toxicity and oxidative stress.
References
Fetoui H, Garoui el M, Makni-Ayadi F, Zeghal N. Oxidative stress induced by lambda-cyhalothrin in rat erythrocytes and brain: Attenuation by vitamin C. Environ Toxicol Pharmacol. 2008; 26(2): 225-231. doi: 10.1016/j.etap.2008.04.002
Amweg EL, Weston DP, Ureda NM. Use and toxicity of py-rethroid pesticides in the central valley, California, USA. Environ Toxicol Chem. 2005; 24(4): 966-972. doi: 10.1897/04-146R1.1
Oros DR, Werner I. Pyrethroid insecticides: An analysis of use patterns, distributions, potential toxicity and fate in the sacramen-to-san joaquin delta and central valley. White paper for the inter-agency ecological program. SFEI contribution 415. San Francisco Estuary Institute, Oakland, CA. 2005.
International programme on chemical safety (IPCS). Environ-mental Health Criteria-99, Cyhalothrin, Geneva. WHO. 1990. 1-99.
Anadon A, Martinez M, Martinez MA, Diaz MJ, Martinez-Lar-ranaga MR. Toxicokinetics of lambda-cyhalothrin in rats. Toxicol Lett. 2006; 165(1): 47-56. doi: 10.1016/j.toxlet.2006.01.014
Ratnasooriya WD, Ratnayake SS, Jayatunga YN. Effects of Icon, a pyrethroid insecticide on early pregnancy of rats. Hum Exp Toxi-col. 2003; 22(10): 523-533. doi: 10.1191/0960327103ht381oa
Barata C, Baird DJ, Nogueira AJ, Soares AM, Riva MC. Tox-icity of binary mixtures of metals and pyrethroid insecticides to daphnia magna straus. Implications for multi-substance risks as-sessment. Aquat Toxicol. 2006; 78(1): 1-14. doi: 10.1016/j.aqua-6 Maiti Choudhury S, et al tox.2006.01.013
Schroer AF, Belgers JD, Brock TC, Matser AM, Maund SJ, Van den Brink PJ. Comparison of laboratory single species and field population-level effects of the pyrethroid insecticide lambda-cy-halothrin on freshwater invertebrates. Arch Environ Contam Toxicol. 2004; 46(3): 324-335. doi: 10.1007/s00244-003-2315-3
Sanborn M, Cole D, Kerr K, Vakil C, Sanin LH, Basil K. System-atic review of pesticides human health effects. The ontario college of family physicians. Ontario, CA, 2004.
AL-Gehani SA. Effect of sub chronic exposure to malathion on haematological parameters in the quail (Coturnixcoturnix). Global Adv Res J Environ Sci Toxicol. 2013; 2: 77-81.
Bertolote JM, Fleischmann A, Eddleston M, Gunnell D. Deaths from pesticide poisoning: A global response. Br J Psychiatry. 2006; 189: 201-203. doi: 10.1192/bjp.bp.105.020834
Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaie A. Pesti-cides and oxidative stress: A review. Med Sci Monit. 2004; 10: 141- 148.
Ames BN, Shigenaga MK, Hagen TM.Oxidants, antioxidants and the degenerative diseases of aging. Proc Natl Acad Sci. 1993; 90: 7915-7922. doi: 10.1073/pnas.90.17.7915
Giray B, Gurbay A, Hincal F. Cypermethrin-induced oxida-tive stress in rat brain and liver is prevented by vitamin E or al-lopurinol. Toxicol Lett. 2001; 118: 139-146. doi: 10.1016/S0378- 4274(00)00277-0
El-Demerdash FM, Yousef MI, Kedwany FS, Baghdadi HH. Role of alpha tochopherol and beta-carotene in ameliorating the fenvalerate induced changes in oxidative stress, hematobiochemi-cal parameters and semen quality of male rats. J Environ Sci Heal B. 2004; 39: 443-459. doi: 10.1081/PFC-120035929
Prasanthi K, Muralidhara, Rajini PS. Fenvalerate-induced oxida-tive damage in rat tissues and its attenuation by dietary sesame oil. Food Chem Toxicol. 2005; 43: 299-306. doi: 10.1016/j.fct.2004.10.005
Schaffer S, Azuma J, Takahashi K, Mozaffari M. Why is tau-rinecytoprotective? Adv Exp Med Biol. 2003; 526: 307-321. doi: 10.1007/978-1-4615-0077-3_39
Trachtman H, Lu P, Sturman JA. Immunohistochemical lo-calization of taurine in rat renal tissue: Studies in experimen-tal disease states. J Histochem Cytochem. 1993; 41: 1209-1216. doi: 10.1177/41.8.8331284
Cruz CI, Ruiz-Torres P, del Moral RG, Rodriguez-Puyol M, Rodriguez-Puyol D. Age-related progressive renal fibro-sis in rats and its prevention with ACE inhibitors and taurine. Am J Physiol Renal Physiol. 2000; 278: F122-F129. doi: 10.1152/ ajprenal.2000.278.1.F122
Sharma CD, Saxena NP, Sharma R. Assessment of clastogenic-ity of lambda-cyhalothrin, a synthetic pyrethroid in cultured lym-phocytes of albino rats. World Appl Sci J. 2010; 8: 1093-1099.
Lowry OH, Roseborough NJ, Farr AL, Randall RL. Protein measurement with Folin phenol reagent. J Biol Chem. 1951; 193: 265-275.
Ohkawa H, Onishi N, Yagi K. Assay for lipid per-oxidation in animal tissue by thiobarbituric acid reaction. Anal Biochem. 1979; 95: 351-358. doi: 10.1016/0003-2697(79)90738-3
Griffith OW. Glutathione turnover in human erythrocytes. J Biol Chem. 1981; 256: 4900-4904.
Griffith MP. Determination of glutathione and glutathione disulphide using glutathione reductase and 2-vinylpyridine. Anal Biochem. 1980; 106: 207-212. doi: 10.1016/0003-2697(80)90139-6
Aebi H. Catalase. In: Bergmeyer HU (Ed). Method of Enzymetic Analysis. NewYork, US: Academic Press. 1974. 674-684.
Rotruck JT, Pope AL, Ganther HC, Hafeman DG, Hoek-stro WG. Selenium: Biochemical role as a component of gluta-thione peroxidase. Science. 1973; 179: 588-590. doi: 10.1126/sci-ence.179.4073.588
Crissman JW, Goodman DJ, Hildebrandt PK, et al. Best prac-tice guideline: Toxicological histopathology. Toxicol Pathol. 2004; 32: 126-131. doi: 10.1080/01926230490268756
Mansour SAK, Abbassy MAL, Shaldam HA. Hepato-renal tox-icity induced by chlorpyrifos, diazinon and their mixture to male rats with special concern to the effect of zinc supplementation. J Toxicol Pharmacol. 2017; 1: 15.
Shukla OP, Omkar AK. Kulshrestha. In: Pesticides, Man and Bio-sphere, 1st Edn. New Delhi, India: APH Publishing Corporation. 1998.
Singh R, Pathak DN. Lipid peroxidation and glutathione per-oxidase, glutathione reductase, superoxide dismutase, Catalase and glucose-6-phosphate dehydrogenase activities in Fecl3 induced epileptogenic foci in the rat brain. Epilepsia. 1990; 31: 15-26. doi: 10.1111/j.1528-1157.1990.tb05354.x
Murthy AS, Priyamvada DA. The effects of endosulfon and its isomers on tissue protein glycogen and lipids in the fish Channapunctatus. Pestic Biochem Physiol. 1982; 17: 280-286. doi: 10.1016/0048-3575 (82)90138-9
Choudhary N, Joshi SC. Reproductive toxicity of endosulfan in male albino rats. Bull Environ Contam toxicol. 2003; 70: 285-289. doi: 10.1007/s00128-002-0189-0 Submit your article to this journal | https://openventio.org/submit-manuscript/ Maiti Choudhury S, et al
Wade MG, Parent S, Finnson KW, et al. Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. Toxicol Sci. 2002; 67: 207-218. doi: 10.1093/ toxsci/67.2.207
Prasad SR. Neurochemical and Histological Studies During the Devel-opment of Behavioural Tolerance to Organophosphate Compound Chlorpyri-fos Toxicity in Albino Rats [dissertation]. Tirupati, India: University of Sri Venkateswara; 2007.
Rahman MF, Siddiqui MKJ. Hematological and clinical chemis-try changes induced by subchronic dosing of a novel phosphoro-thionate (RPR-V) in Wistar male and female rats. Drug Chem Toxi-col. 2006; 29: 95-110. doi: 10.1080/01480540500408697
Kishandar N. Neurotoxicity Effects of Neonicotinoid Insecticide Imi-dacloprid in Albino Rat. Insedicidebideclopid in Albin, Rat [dissertation]. Tirupati, India: University of Sri Venkateswara; 2007; 7: 83-90.
Sukanya N. Neurotoxic Effect of Cypermethrin in Wistar Strain Rats: A Biochemical, Behavioral and Histological Study [dissertation]. Tirupati, India: University of Sri Venkateswara; 2007.
Sener G, Sehirli O, Cetinel S, et al. Amelioration of sepsis-induced hepatic and ileal injury in rats by the leukotriene receptor blocker montelukast. Prostaglandins Leukot Essent Fatty Acids. 2005; 73: 453-460. doi: 10.1016/j.plefa.2005.07.008
El-Deib KM, Ahmed MM, Ahmed NZ. Biochemical evalua-tion of the protective impact of silymarin against cyclophospha-mide induced hepatotoxicity in rats. Egypt J Biochem Mol Biol. 2011; 29: 291-310. doi: 10.4314/ejbmb.v29i2.72440
Fetoui H, Makni M, Garoui el M, Zeghal N. Toxic effects of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the rat kidney: Involvement of oxidative stress and protective role of ascorbicacid. Exp Toxicol Pathol. 2010; 62: 593-599. doi: 10.1016/j. etp.2009.08.004
Ansari RW, Shukla RK, Yadav RS, et al. Cholinergic dysfunc-tions and enhanced oxidative stress in the neurobehavioral toxicity of lambda-cyhalothrin in developing rats. Neurotox Res. 2012; 22: 292-309. doi: 10.1007/s12640-012-9313-z
Salama AK, Osman KA, Saber NA, Soliman SA. Oxidative stress induced by different pesticides in the land snails, Helix asper-sa. Pak J Biol Sci. 2005; 8: 92-96. doi: 10.3923/pjbs.2005.92.96
Franconi F, Di Leo MA, Bennardini F, Ghirlanda G. Is taurine beneficial in reducing risk factors for diabetes mellitus. Neurochem Res. 2004; 29: 143-150. doi: 10.1023/B:NERE.0000010443.05899 .2f
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in Toxicology and Forensic Medicine (TFM) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.
