Endometriosis Research: Need for a Stem-Cell Based Experimental Model

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Authors

  • Parveen Parasar Boston Center for Endometriosis, Brigham and Women’s Hospital, Boston Children’s Hospi- tal, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA

DOI:

https://doi.org/10.17140/GOROJ-2-e003

Keywords:

Endometriosis, Stem cells, Experimental model

Abstract

Endometriosis is a complex disease and not a single phenotype can be delineated in available in vitro models. A comparative analysis of pluripotent stem cells in normal endometrium and endometriosis will give an understanding of status of biomarkers in endometrium and endometriosis, respectively. Highly pluripotent stem cells are critically important constituents of endometrium and contribute to ectopic endometriotic implants as reported in various studies. Because stem cells are undifferentiated and possess tremendous regenerative capacity, they are candidate cellular system for modeling endometriosis.

References

Finn CA. Why do women and some other primates menstru-ate? Perspect Biol. Med. 1987; 30(4): 566-574.

Sampson JA. Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am. J. Pathol. 1927; 3(2): 93-110.

Sasson IE, Taylor HS. Stem cells and the pathogenesis of Page e7 endometriosis. Ann N Y Acad. Sci. 2008; 1127: 106-115. doi: 10.1196/annals.1434.014

Figueira PG, Abrão MS, Krikun G, Taylor HS. Stem cells in endometrium and their role in the pathogenesis of endometriosis. Ann N Y Acad Sci. 2011; 1221(1): 10-17. doi: 10.1111/j.1749- 6632.2011.05969.x

Giudice LC, Kao LC. Endometriosis. Lancet. 2004; 364(9447): 1789-1799.

Vercellini P, Viganò P, Somigliana E, Fedele L. Endometri-osis: pathogenesis and treatment. Nat. Rev. Endocrinol. 2014; 10(5): 261-275. doi: 10.1038/nrendo.2013.255

Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of en-dometriosis on quality of life and work productivity: a multi-center study across ten countries. Fertil Steril. 2011; 96(2): 366- 373. doi: 10.1016/j.fertnstert.2011.05.090

Bruner-Tran KL, Herington JL, Duleba AJ, Taylor HS, Osteen KG. Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Gine-col. 2013, 65(2): 199-213.

De Graaf AA, D’Hooghe TM, Dunselman GA, et al. The sig-nificant effect of endometriosis on physical, mental and social wellbeing: results from an international cross-sectional survey. Hum. Reprod. 2013; 28(10): 2677-2685. doi: 10.1093/humrep/ det284

Laufer MR, Goitein L, Bush M, Cramer DW, Emans SJ. Prevalence of endometriosis in adolescent girls with chronic pelvic pain not responding to conventional therapy. J. Pediatr. Adolesc. Gynecol. 1997; 10(4): 199-202. doi: 10.1016/S1083- 3188(97)70085-8

Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of laparoscopically con-firmed endometriosis by demographic, anthropometric, and lifestyle factors. Am. J. Epidemiol. 2004; 160(8): 784-796. doi: 10.1093/aje/kwh275

Vercellini P, Somigliana E, Buggio L, Bolis G, Fedele L. Endometriosis and ovarian cancer. Lancet Oncol. 2012; 13(5): e188-e189.

Painter JN, Anderson CA, Nyholt DR, et al. Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat. Genet. 2011; 43(1): 51-54. doi: 10.1038/ ng.731

Rahmioglu N, Nyholt DR, Morris AP, Missmer SA, Mont-gomery GW, Zondervan KT. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-Gynecol Obstet Res Open J wide association and replication datasets. Hum. Reprod. Update. 2014; 20(5): 702-716. doi: 10.1093/humupd/dmu015

Ferguson BR, Bennington JL, Haber SL. Histochemistry of mucosubstances and histology of mixed müllerian pelvic lymph node glandular inclusions. Evidence for histogenesis by mülle-rian metaplasia of coelomic epithelium. Obstet. Gynecol. 1969; 33(5): 617-625.

Sterneckert JL, Reinhardt P, Schöler HR. Investigating hu-man disease using stem cell models. Nat Rev Genet. 2014; 15(9): 625-639. doi: 10.1038/nrg3764

Padykula HA, Coles LG, Okulicz WC, et al. The basalis of the primate endometrium: a bifunctional germinal compart-ment. Biol. Reprod. 1989; 40(3): 681-690. doi: 10.1095/ biolre-prod40.3.681

Gargett CE, Chan RW, Schwab KE. Endometrial stem cells. Curr. Opin. Obstet. Gynecol. 2007; 19(4): 377-383.

Du H, Taylor HS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 2007; 25(8): 2082-2086. doi: 10.1634/stemcells.2006-0828

Deane JA, Gualano RC, Gargett CE. Regenerating endome-trium from stem/progenitor cells: is it abnormal in endometriosis, Asherman’s syndrome and infertility? Curr Opin Obstet Gynecol. 2013; 25(3): 193-200. doi: 10.1097/GCO.0b013e32836024e7 Page e8

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Published

2015-07-13

How to Cite

Parveen Parasar. (2015). Endometriosis Research: Need for a Stem-Cell Based Experimental Model. Gynecology and Obstetrics Research, 2(3), e6-e8. https://doi.org/10.17140/GOROJ-2-e003

Issue

Vol. 2 No. 3 (2015): Volume 2 Issue 3 2015

Section

Articles

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All content published in Gynecology and Obstetrics Research (GOR) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.