Involvement of NF-κB Signaling Pathway in the Pathogenesis of Systemic Lupus Erythematosus

Authors

  • Rakesh K. Mishra, PhD

Keywords:

Systemic lupus erythematosus (SLE); Nuclear factor kappa binding (NF-κB); Lupus; Toll-like receptors (TLRs).

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by accumulation of anti-nuclear autoantibodies, hyperactivation. It can affect any organ, including
brain, skin, joint, and kidney. The nuclear NF-κB pathway has long been considered a crucial
pro- inflammatory signaling pathway. Its transcribed the genes involves in various autoimmune
disease. Within the past year, many research studies have been conducted the role of NF-κB
signaling in lupus. In this review, we will highlight some recent studies that support the potential link of NF-κB signaling pathway which play a crucial role in the pathogenesis of SLE.

Downloads

Published

2016-05-31

How to Cite

Rakesh K. Mishra, PhD. (2016). Involvement of NF-κB Signaling Pathway in the Pathogenesis of Systemic Lupus Erythematosus. Nephrology, 9–13. Retrieved from https://openventio.us/index.php/NOJ/article/view/2293

Issue

Volume 2 Issue 1 2016

Section

Articles

License

All content published in Nephrology – Open Journal (NOJ) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.