Liposomal Vitamin A: Emerging Trends in Nanometric Delivery, Manufacturing, and Therapeutic Outcomes

Abstract

Vitamin A is a vital fat-soluble micronutrient essential for vision, immune function, and skin health, yet
its therapeutic potential is frequently limited by poor aqueous solubility, chemical instability, and low
oral bioavailability. Traditional delivery methods often fail to protect this sensitive retinoid from oxidative
degradation and first-pass metabolism. This review explores the emergence of liposomal encapsulation as a
transformative strategy to overcome these barriers. By embedding Vitamin A within phospholipid bilayers,
liposomes enhance its stability, shield it from harsh gastrointestinal conditions, and facilitate superior
absorption through biomimetic membrane interaction and lymphatic transport pathways.

The article examines the formulation chemistry, manufacturing technologies—such as high-pressure homog-
enization and critical characterization parameters including particle size, zeta potential, and encapsulation

efficiency. Furthermore, it highlights the clinical implications of targeted delivery in both nutrition and der-
matology, where liposomal systems provide a controlled-release mechanism that reduces systemic toxicity

and local irritation. A specific focus is placed on industrial advancements such as LipoedgeTM technology,

which demonstrates a significant 2.36-fold increase in bioavailability. This review concludes that liposo-
mal Vitamin A represents a superior alternative to conventional formulations, offering a precision-based

approach to nutrient delivery and therapeutic skin care.