Mitochondrial Antioxidant Enzymes and Endurance Exercise-induced Cardioprotection against Ischemia-Reperfusion Injury
DOI:
https://doi.org/10.17140/SEMOJ-4-155Keywords:
Endurance exercise, Mitochondria, Antioxidant enzymes, Ischemia reperfusion, CardioprotectionAbstract
Coronary artery disease (CAD) is the most common cause of myocardial injuries induced by prolonged cessation of blood flow (ischemia) to cardiac myocytes due to atherosclerosis. For several decades, many clinical trials have been applied to protect hearts against ischemia and reperfusion (I/R) injuries, but failed to show significant improvement in the restoration of cardiac function. By contrast, growing evidence has shown that a non-pharmacological strategy, endurance exercise, provides cardioprotection against ischemic myocardial injuries. Despite the prominent cardioprotective benefit; however, the exact molecular and cellular protective mechanisms remain an exciting issue. Nonetheless, given that excess production of reactive oxygen species (ROS) is a primary mediator of cardiac injuries caused by an I/R insult, improved myocardial antioxidant capacity in response to endurance exercise has been suggested to be a key mechanism against I/R injuries, in particular, Therefore, this review will focus the role of endurance exercise-induced improvement in myocardial antioxidants in cardioprotection against I/R induced myocardial infarction.
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