Coronavirus Disease-2019 Infection-Associated Glomerular Diseases

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Authors

  • Phuong-Chi T. Pham, MD Olive View-UCLA Medical Center, Sylmar, CA 91342, USA
  • Golriz Jafari, MD Olive View-UCLA Medical Center, Sylmar, CA 91342, USA
  • Anita Kamarzarian, MD Olive View-UCLA Medical Center, Sylmar, CA 91342, USA
  • Vinod K. Valluri, MD Olive View-UCLA Medical Center, Sylmar, CA 91342, USA
  • Kulwant Bath, MD Olive View-UCLA Medical Center, Sylmar, CA 91342, USA
  • Chau Sally, Olive View-UCLA Medical Center, Sylmar, CA 91342, USA
  • Nguyen Tuan, DO Olive View-UCLA Medical Center, Sylmar, CA 91342, USA
  • Mahalli Joseph, DO Olive View-UCLA Medical Center, Sylmar, CA 91342, USA
  • Phuong-Mai T. Pham, MD Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA
  • Phuong-Anh T. Pham, MD VA Hospital in Tulsa, Tulsa, OK 74133, USA
  • Son V. Pham, MD Phoenix Healthcare System, Veterans Administrations, Phoenix, AZ, USA
  • Phuong-Thu T. Pham, MD Ronald Reagan Medical Center at David Geffen School of Medicine, Los Angeles, CA 90095, USA

DOI:

https://doi.org/10.17140/npoj-8-129

Keywords:

COVID-19; SARS; Glomerular diseases; Focal segmental glomerulosclerosis; ANCA vasculitis; IgA nephropathy; Thrombotic microangiopathy; Thrombotic thrombocytopenic purpura.

Abstract

Background
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus pandemic of 2019 (coronavirus disease-2019 (COVID-19)) has led to unimaginable global deaths and serious morbidities among survivors. From a renal perspective, COVID-19
was also reported to be complicated by glomerular diseases. We herein present a systematic review of the distributive pattern of
glomerular diseases (GNs) reported in association with COVID-19 infection.
Methods
We searched National Library of Medicine’s (NLM), Excerpta Medica Database (EMBASE) and the World Health Organization’s
(WHO) COVID-19 database for case reports, case series, and observational studies that reported GNs associated with COVID-19
infection. Two reviewers independently extracted relevant data. The current study was registered with Research Registry #1736
on November 20, 2023.
Results
Of the 1261 articles identified, fifty-eight articles pertained to COVID-19 infection-related GNs. One hundred sixty-two de novo
GN cases were claimed to be related to the COVID-19 infection. Among these, the top 3 were focal segmental glomerulosclerosis
(focal segmental glomerulosclerosis (FSGS), 90 out of 162, 55.6%), antineutrophil cytoplasmic autoantibody (ANCA)-associated
GN (34 out of 162, 21.0%), and IgA nephropathy (IgAN) and thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, or not specified) (both with 12 out of 162, 7.4%). In comparison, excluding
diabetic kidney disease, the top 3 GNs globally in the pre-COVID era were FSGS (17.4%), IgAN (16.5%), and membranous
nephropathy (MN) (12.1%).
Conclusion
Although most commonly reported, FSGS was not the only GN associated with COVID-19. The distributive pattern of GNs
reported to be associated with COVID-19 infection differed significantly compared with that in the pre-COVID era. This difference may lend support to COVID-19 related effects on the most commonly reported GNs.

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Published

2024-01-29

How to Cite

Phuong-Chi T. Pham, MD, Golriz Jafari, MD, Anita Kamarzarian, MD, Vinod K. Valluri, MD, Kulwant Bath, MD, Chau Sally, … Phuong-Thu T. Pham, MD. (2024). Coronavirus Disease-2019 Infection-Associated Glomerular Diseases. Nephrology, 8(1), 1–6. https://doi.org/10.17140/npoj-8-129

Issue

Volume 8 Issue 1 2024

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