Pediatric Genitourinary Tumors-Clinicopathological Experience
DOI:
https://doi.org/10.17140/NPOJ-1-108Keywords:
Genitourinary; Childhood tumors; Wilm’s tumor; Neuroblastoma; Germ cell tumor.Abstract
Objective: To document general baseline data on the patterns of childhood genitourinary tumors.
Design, Setting and Participants: This is a retrospective analysis of 28 cases of pediatric genitourinary tumors (Age group 0-12 years) in surgical pathology in a tertiary care hospital encountered over a period of 5 years.
Results: In the genitourinary system tumors of the kidney, bladder, prostate, testis, and adrenal
were included. A total of 3149 pediatric surgical specimen presented over a five years. Of this,
28 were diagnosed with genitourinary tumors. In the renal tumors only Wilm’s tumors (WTs) (9
cases) was seen, with classical triphasic tumors were more common. The mean age of presentation is 3 year with commonest age group of presentation (8 cases out of 9) in the age group 1-5
years. Three of them had showed unfavorable histology. Among the gonadal germ cell tumors,
there were noted four mature teratoma, one immature teratoma, two yolk sac tumors of ovary
& one yolk sac tumour in testis was seen. In the adrenal gland, adrenal medullary tumors were
more common than adrenal cortex with neuroblastoma (4 of 10 cases) as common individual
tumor.
Conclusion: Different types of genitourinary tumors seen in the childhood. A high index of
suspicion should be maintained with an aim of surgical treatment to avoid the poor management. Histological type is important for understanding etiology and progression of disease. The
likelihood of a given type of tumor being present in a particular age or sex group or particular
site may heighten the index of suspicion and ultimately influences etiology, biology, and natural
history, relative incidence and distribution frequency, clinical presentation and manifestations,
and response to therapy and outcome.”
References
Lowe LH, Isuani BH, Heller RM, et al. Pediatric renal masses: Wilms tumor and beyond. Radiographics. 2000; 20(6): 1585. doi: 10.1148/radiographics.20.6.g00nv051585
Spreafico F, Bellani FF. Wilms’ tumor: past, present and (pos-sibly) future. Expert Rev Anticancer Ther. 2006; 6(2): 249. doi: 10.1586/14737140.6.2.249
van den Heuvel-Eibrink MM, Grundy P, Graf N. Character-istics and survival of 750 children diagnosed with a renal tu-mor in the first seven months of life: a collaborative study by the SIOP/GPOH/SFOP, NWTSG, and UKCCSG Wilms tumor study groups. Pediatr Blood Cancer. 2008; 50(6): 1130-1134. doi: 10.1002/pbc.21389
Breen J, Denehy T. Pediatric ovarian malignancies. Glob libr women’s med. 2008. doi: 10.3843/GLOWM.10251
Taskinen S, Fagerholm R, Aronniemi J, et al. Testicular tu-mors in children and adolescents. J Pediatr Urol. 2008; 4(2): 134-137. doi: 10.1016/j.jpurol.2007.10.002
Steliarova-Foucher E, Hery C, Pisanim P. The burden of child-hood cancer. International Union against Cancer, UICC. 2006.
Louisa P, Durrane T, Suhail M, Irshad N, Zafar N, Sheema H. Clinicopathological profile of Wilms’ tumor. Indian Journal of Pediatrics. 2000; 67(10): 765-767.
Stocker JT, Dehner LP, Husain AN, Ovid Technologies, Inc. Stocker & Dehner’s pediatric pathology. 3rd ed. Philadelphia: Lippincot Williams & Wilkins; 2001.
Breslow NE, Beckwith JB. Epidemiological features of Wilms tumor: results of the national wilms’ tumor study. Journal of the National Cancer Institute. 1982; 68(3): 429-436.
Patel A, Patel K, Shah S, et al. Three years experience of infantile Wilms tumour at a single institute in a developing coun-try. Journal of Clinical Oncology. 2007; 25(18S): 20028.
Audrey E, Giulio J. Age at diagnosis and prognosis in chil-dren with neuroblastoma. Journal of Clinical Oncology. 2005; 23(27): 6443-6444. doi: 10.1200/JCO.2005.05.005
London W, Castleberry R, Matthay K, et al. Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the children’s oncology group. J ClinOncol. 2005; 23(27): 6459-6465. doi: 10.1200/JCO.2005.05.571
Ng L, Libertino JM. Adrenocortical carcinoma: diagnosis, evaluation and treatment. J Urol. 2003; 169: 5-11. doi: 10.1016/ S0022-5347(05)64023-2
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