Recent Advances in Fibro-blast Growth Factor-23 Functions
Keywords:
controversial, coexpressions, fibroblastAbstract
During the past decade a lot of work has been done to better understand the roles
of fibroblast growth factor-23 (FGF-23); a relatively newly discovered endocrine hormone,
in multiple organ systems in the body. This review focuses on expressions of FGF-23, coexpressions of α-Klotho and FGF receptors, and FGF-23 mediated end-organ effects in the
physiological and pathological conditions. We also discuss the controversial reports regarding
α-Klotho-dependent and α-Klotho-independent functions of FGF-23.
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All content published in Nephrology – Open Journal (NOJ) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.