Recent Advances in Fibro-blast Growth Factor-23 Functions

Abstract

During the past decade a lot of work has been done to better understand the roles
of fibroblast growth factor-23 (FGF-23); a relatively newly discovered endocrine hormone,
in multiple organ systems in the body. This review focuses on expressions of FGF-23, coexpressions of α-Klotho and FGF receptors, and FGF-23 mediated end-organ effects in the
physiological and pathological conditions. We also discuss the controversial reports regarding
α-Klotho-dependent and α-Klotho-independent functions of FGF-23.