Involvement of NF-κB Signaling Pathway in the Pathogenesis of Systemic Lupus Erythematosus
Keywords:
Systemic lupus erythematosus (SLE); Nuclear factor kappa binding (NF-κB); Lupus; Toll-like receptors (TLRs).Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by accumulation of anti-nuclear autoantibodies, hyperactivation. It can affect any organ, including
brain, skin, joint, and kidney. The nuclear NF-κB pathway has long been considered a crucial
pro- inflammatory signaling pathway. Its transcribed the genes involves in various autoimmune
disease. Within the past year, many research studies have been conducted the role of NF-κB
signaling in lupus. In this review, we will highlight some recent studies that support the potential link of NF-κB signaling pathway which play a crucial role in the pathogenesis of SLE.
