A New Hypothesis: The Immunomodulatory Effects of Mesenchymal Stromal Cell Derived Extracellular Vesicles in Ischemic Kidney Injury Partly through Spleen

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Authors

  • Zou Xiangyu Department of Urology, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR 200080, China
  • Zhu Yingjian Department of Urology, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR 200080, China

DOI:

https://doi.org/10.17140/NPOJ-1-105

Keywords:

Mesenchymal stromal cell; Extracellular vesicles; Ischemic kidney injury; Immunomodulatory

Abstract

Ischemic Reperfusion Injury (IRI) is a major reason for Acute Kidney Injury (AKI) in
hospitalization patients and could continue to result in end-stage kidney fibrosis. Mesenchymal
Stromal Cells (MSCs) are regarded as a promising therapeutic method for AKI, but the potential ethical and tumorigenesis problems of MSCs limit clinical use. Recently Extracellular
Vesicles (EVs) that contained in the MSCs’ condition medium were also found having a vital
therapeutic effect in IRI induced AKI. As for the pluripotent prosperities of MSCs, MSC-EVs
contain various bioactive substances that participate in the tissue repair and the immunomodulatory effect of MSC-EVs has been regarded as a crucial role in ischemic kidney injury and repair. However, the true mechanism still unknown. Based on existed facts, we hypothesized that
the immunomodulatory effect of MSC-EVs in ischemic kidney injury partly through spleen.

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Published

2015-07-30

How to Cite

Zou Xiangyu, & Zhu Yingjian. (2015). A New Hypothesis: The Immunomodulatory Effects of Mesenchymal Stromal Cell Derived Extracellular Vesicles in Ischemic Kidney Injury Partly through Spleen. Nephrology, 1(2), 25–29. https://doi.org/10.17140/NPOJ-1-105

Issue

Volume 1 Issue 2 2015

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Articles

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