Androgen and Androgen Receptor in Kidney Cancer

Abstract

Kidney cancer is one of the top ten most common cancers in men and women. There
are four types of kidney cancer, including Renal Cell Carcinoma (RCC), Transitional cell
carcinoma, renal sarcoma, and Wilm’s tumor. The most common type of kidney cancers is
renal cell carcinoma (RCC), with around nine out of ten kidney cancers being RCC (American
Cancer Associate). Epidemiology studies have identified several risk factors associated with
kidney cancer.1 Among them, male gender is associated with twice incidence rate of RCC
as female.2
Androgen and Androgen Receptor (AR) are major factors contributing to malegender-associated-diseases, such as prostate cancer,3
suggesting that androgen and AR might
be involved in RCC development and progression