Traumatic Brain Injury: An Update
DOI:
https://doi.org/10.17140/SROJ-4-e003Keywords:
Traumatic brain injury (TBI), United States, injuryAbstract
Traumatic brain injury (TBI) remains one of the leading causes of trauma-related mortality and morbidity in the United States. An estimated 2.5 million TBI occur annually resulting in 282,000 hospitalization and 50,000 deaths with an estimated economic burden of $141 billion. While TBI accounts for 30% of all injury related deaths, survivors face physical and cognitive disabilities together with an increasing risk for neurodegenerative diseases and lasting effects on the individual, the family and the community.
References
CDC Report. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002-2006 (Blue Book). 2010. Web site. https://www.cdc.gov/traumaticbraininjury/tbi_ed.html. Accessed September 7, 2017.
Taylor CA, Bell JM, Breiding MJ, Xu L. Traumatic brain injury-related emergency department visits, hospitalizations, and deaths - United States, 2007 and 2013. MMWR Surveill Summ. 2017 66(9): 1-16. doi: 10.15585/mmwr.ss6609a1
Barnes DE, Kaup A, Kirby KA, Byers AL, Diaz-Arrastia R, Yaffe K. Traumatic brain injury and risk of dementia in older veterans. Neurology. 2014; 83(4): 312-319. doi: 10.1212/WNL.0000000000000616
Hutson CB, Lazo CR, Mortazavi F, Giza CC, Hovda D, Chesselet MF. Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat. J Neurotrauma. 2011; 28(9): 1783-1801. doi: 10.1089/neu.2010.1723
Molloy C, Conroy RM, Cotter DR, Cannon M. Is traumatic brain injury a risk factor for schizophrenia? A meta-analysis of case-controlled population-based studies. Schizophr Bull. 2011 37(6): 1104-1110. doi: 10.1093/schbul/sbr091
Webster KM, Sun M, Crack P, O’Brien TJ, Shultz SR, Semple BD. Inflammation in epileptogenesis after traumatic brain injury. J Neuroinflammation. 2017; 14(1): 10. doi: 10.1186/s12974-016-0786-1
Werner C, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth. 2007; 99(1): 4-9. doi: 10.1093/bja/aem131
Harhangi BS, Kompanje EJ, Leebeek FW, Maas AI. Coagulation disorders after traumatic brain injury. Acta Neurochir (Wien). 2008; 150(2): 165-175. doi: 10.1007/s00701-007-1475-8
Uzzell BP, Dolinskas CA, Wiser RF. Relation between intracranial pressure, computed tomographic lesion, and neuropsychologi-cal outcome. Adv Neurol. 1990; 52: 269-274.
Uzzell BP, Dolinskas CA, Wiser RF, Langfitt TW. Influence of lesions detected by computed tomography on outcome and neu-ropsychological recovery after severe head injury. Neurosurgery. 1987; 20(3): 396-402. doi: 10.1227/00006123-198703000-00007
Badri S, Chen J, Barber J, et al. Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury. Intensive Care Med. 2012; 38(11): 1800-1809. doi: 10.1007/s00134-012-2655-4
Chesnut RM, Temkin N, Carney N, et al. A trial of intracranial-pressure monitoring in traumatic brain injury. N Engl J Med. 2012; 367 (26): 2471-2481. doi: 10.1056/NEJMoa1207363
McConeghy KW, Hatton J, Hughes L, Cook AM. A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury. CNS Drugs. 2012; 26(7): 613-636. doi: 10.2165/11634020-000000000-00000
Cooper PR, Moody S, Clark WK, et al. Dexamethasone and severe head injury. A prospective double-blind study. J Neurosurg. 1979; 51(3): 307-316. doi: 10.3171/jns.1979.51.3.0307
Kabadi SV, Faden AI. Neuroprotective strategies for traumatic brain injury: Improving clinical translation. Int J Mol Sci. 2014; 15(1): 1216-1236. doi: 10.3390/ijms15011216
McIntosh TK, Vink R, Soares H, Hayes R, Simon R. Effects of the N-methyl-D-aspartate receptor blocker MK-801 on neuro-logic function after experimental brain injury. J Neurotrauma. 1989; 6(4): 247-259. doi: 10.1089/neu.1989.6.247
Fei Z, Zhang X, Bai HM, Jiang XF, Wang XL. Metabotropic glutamate receptor antagonists and agonists: Potential neuroprotec-tors in diffuse brain injury. J Clin Neurosci. 2006; 13(10): 1023-1027. doi: 10.1016/j.jocn.2005.11.042
Marshall LF, Maas AI, Marshall SB, et al. A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury. J Neurosurg. 1998; 89(4): 519-525. doi: 10.3171/jns.1998.89.4.0519
Cook AM, Whitlow J, Hatton J, Young B. Cyclosporine A for neuroprotection: Establishing dosing guidelines for safe and effec-tive use. Expert Opin Drug Saf. 2009; 8(4): 411-419. doi: 10.1517/14740330903066742
Hatton J, Rosbolt B, Empey P, Kryscio R, Young B. Dosing and safety of cyclosporine in patients with severe brain injury. J Neurosurg. 2008; 109(4): 699-707. doi: 10.3171/JNS/2008/109/10/0699
Wible EF, Laskowitz DT. Statins in traumatic brain injury. Neurotherapeutics. 2010; 7(1): 62-73. doi: 10.1016/j.nurt.2009.11.003
Stein DG. Is progesterone a worthy candidate as a novel therapy for traumatic brain injury? Dialogues Clin Neurosci. 2011 13(3): 352-359.
Stein DG, Wright DW, Kellermann AL. Does progesterone have neuroprotective properties? Ann Emerg Med. 2008; 51(2): 164- 172. doi: 10.1016/j.annemergmed.2007.05.001
Busto R, Dietrich WD, Globus MY, Ginsberg MD. Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosci Lett. 1989; 101(3): 299-304. doi: 10.1016/0304-3940(89)90549-1
Chakraborty S, Skolnick B, Narayan RK. Neuroprotection trials in traumatic brain injury. Curr Neurol Neurosci Rep. 2016; 16 (4): 29. doi: 10.1007/s11910-016-0625-x
Schouten JW. Neuroprotection in traumatic brain injury: A complex struggle against the biology of nature. Curr Opin Crit Care. 2007; 13(2): 134-142. doi 10.1097/MCC.0b013e3280895d5c
Tan CO, Meehan WP, III, Iverson GL, Taylor JA. Cerebrovascular regulation, exercise, and mild traumatic brain injury. Neurol-ogy. 2014 83(18): 1665-1672. doi: 10.1212/WNL.0000000000000944
Harris JL, Yeh HW, Choi IY, et al. Altered neurochemical profile after traumatic brain injury: (1)H-MRS biomarkers of patho-logical mechanisms. J Cereb Blood Flow Metab. 2012; 32(12): 2122-2134. doi: 10.1038/jcbfm.2012.114
Harris NG, Mironova YA, Chen SF, Richards HK, Pickard JD. Preventing flow-metabolism uncoupling acutely reduces axonal injury after traumatic brain injury. J Neurotrauma. 2012; 29(7): 1469-1482. doi: 10.1089/neu.2011.2161
Lam JM, Hsiang JN, Poon WS. Monitoring of autoregulation using laser Doppler flowmetry in patients with head injury. J Neu-rosurg. 1997; 86(3): 438-445. doi: 10.3171/jns.1997.86.3.0438
Richards HK, Simac S, Piechnik S, Pickard JD. Uncoupling of cerebral blood flow and metabolism after cerebral contusion in the rat. J Cereb Blood Flow Metab. 2001; 21(7): 779-781. doi: 10.1097/00004647-200107000-00002
Heusch G. Molecular basis of cardioprotection: Signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res 116(4): 674-699, 2015. doi: 10.1161/CIRCRESAHA.116.305348
Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: Underlying mechanisms and clinical application. Atheroscle-rosis. 2009; 204(2): 334-341. doi: 10.1016/j.atherosclerosis.2008.10.029
Kanoria S, Jalan R, Seifalian AM, Williams R, Davidson BR. Protocols and mechanisms for remote ischemic preconditioning: A novel method for reducing ischemia reperfusion injury. Transplantation. 2007; 84(4): 445-458. doi: 10.1097/01.tp.0000228235.55419
Sharma R, Randhawa PK, Singh N, Jaggi AS. Bradykinin in ischemic conditioning-induced tissue protection: Evidences and possible mechanisms. Eur J Pharmacol. 2015; 768: 58-70. doi: 10.1016/j.ejphar.2015.10.029
Tapuria N, Kumar Y, Habib MM, Abu AM, Seifalian AM, Davidson BR. Remote ischemic preconditioning: A novel protective method from ischemia reperfusion injury--a review. J Surg Res. 2008; 150(2): 304-330. doi: 10.1016/j.jss.2007.12.747
Turrell HE, Thaitirarot C, Crumbie H, Rodrigo G. Remote ischemic preconditioning of cardiomyocytes inhibits the mitochon-drial permeability transition pore independently of reduced calcium-loading or sarcKATP channel activation. Physiol Rep. 2014; 2(11): e12231. doi: 10.14814/phy2.12231
Jose Alburquerque-Bejar J, Barba I, Valls-Lacalle L, et al. Remote ischemic conditioning provides humoural cross-species car-dioprotection through glycine receptor activation. Cardiovasc Res. 113(1): 52-60. doi: 10.1093/cvr/cvw242
Cuomo O, Vinciguerra A, Cerullo P, et al. Ionic homeostasis in brain conditioning. 2015; Front Neurosci. 9: 277. doi: 10.3389/ fnins.2015.00277
Kanoria S, Jalan R, Davies NA, Seifalian AM, Williams R, Davidson BR. Remote ischaemic preconditioning of the hind limb reduces experimental liver warm ischaemia-reperfusion injury. Br J Surg. 2006; 93(6): 762-768. doi: 10.1002/bjs.5331
Kierulf-Lassen C, Kristensen ML, Birn H, Jespersen B, Norregaard R. No effect of remote ischemic conditioning strategies on recovery from renal ischemia-reperfusion injury and protective molecular mediators. PLoS One. 2015; 10(12): e0146109. doi: 10.1371/journal.pone.0146109
Kono Y, Fukuda S, Hanatani A, et al. Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure. Drug Des Devel Ther. 2014; 8: 1175-1181. doi: 10.2147/DDDT.S68715
England TJ, Hedstrom A, O’Sullivan S, et al. RECAST (Remote Ischemic Conditioning After Stroke Trial): A pilot randomized placebo controlled phase II trial in acute ischemic stroke. Stroke. 2017; 48(5): 1412-1415. doi: 10.1161/STROKEAHA.116.016429
Gonzalez NR, Connolly M, Dusick JR, Bhakta H, Vespa P. Phase I clinical trial for the feasibility and safety of remote ischemic conditioning for aneurysmal subarachnoid hemorrhage. Neurosurgery. 2014; 75(5): 590-598. doi: 10.1227/NEU.0000000000000514
Koch S, Katsnelson M, Dong C, Perez-Pinzon M. Remote ischemic limb preconditioning after subarachnoid hemorrhage: A phase Ib study of safety and feasibility. Stroke. 2011; 42(5): 1387-1391. doi: 10.1161/STROKEAHA.110.605840
Tulu S, Mulino M, Pinggera D, et al. Remote ischemic preconditioning in the prevention of ischemic brain damage during intracranial aneurysm treatment (RIPAT): Study protocol for a randomized controlled trial. Trials. 2015; 16: 594. doi: 10.1186/ s13063-015-1102-6
Joseph B, Pandit V, Zangbar B, et al. Secondary brain injury in trauma patients: The effects of remote ischemic conditioning. J Trauma Acute Care Surg. 2015; 78(4): 698-703. doi: 10.1097/TA.0000000000000584
Alali AS, Mukherjee K, McCredie VA, et al. Beta-blockers and traumatic brain injury: A systematic review, meta-analysis, and Eastern Association for the surgery of trauma guideline. Ann Surg. 2017; doi: 10.1097/SLA.0000000000002286
Chen Z, Tang L, Xu X, Wei X, Wen L, Xie Q. Therapeutic effect of beta-blocker in patients with traumatic brain injury: A sys-tematic review and meta-analysis. J Crit Care. 2017; 41: 240-246. doi: 10.1016/j.jcrc.2017.05.035
Kota DJ, Prabhakara KS, van Brummen AJ, et al. Propranolol and mesenchymal stromal cells combine to treat traumatic brain injury. Stem Cells Transl Med. 2016; 5(1): 33-44. doi: 10.5966/sctm.2015-0065
Ley EJ, Scehnet J, Park R, et al. The in vivo effect of propranolol on cerebral perfusion and hypoxia after traumatic brain injury. J Trauma. 2009; 66(1): 154-159. doi: 10.1097/TA.0b013e31819388be
Ley EJ, Clond MA, Bukur M, et al. Beta-adrenergic receptor inhibition affects cerebral glucose metabolism, motor perfor-mance, and inflammatory response after traumatic brain injury. J Trauma Acute Care Surg. 2012; 73(1): 33-40. doi: 10.1097/ TA.0b013e31825a769b
Liu MY. Protective effects of propranolol on experimentally head-injured mouse brains. J Formos Med Assoc. 1995; 94(7): 386-390.
Loftus TJ, Efron PA, Moldawer LL, Mohr AM. Beta-blockade use for traumatic injuries and immunomodulation: A review of proposed mechanisms and clinical evidence. Shock. 2016; 46(4): 341-351. doi: 10.1097/SHK.0000000000000636
Mohseni S, Talving P, Thelin EP, Wallin G, Ljungqvist O, Riddez L. The Effect of beta-blockade on survival after isolated severe traumatic brain injury. World J Surg. 2015; 39(8): 2076-2083. doi: 10.1007/s00268-015-3039-z
Murry JS, Hoang DM, Barmparas G, et al. Prospective evaluation of early propranolol after traumatic brain injury. J Surg Res. 2016; 200(1): 221-226. doi: 10.1016/j.jss.2015.06.045
Schroeppel TJ, Fischer PE, Zarzaur BL, et al. Beta-adrenergic blockade and traumatic brain injury: Protective? J Trauma. 2010; 69(4): 776-782. doi: 10.1097/TA.0b013e3181e981b8
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