The Opportunistic Salpingectomy in Reducing Ovarian Cancer Risk: Do the Potential Benefits Outweigh Complications?
DOI:
https://doi.org/10.17140/SROJ-3-118Keywords:
Cancer, Fallopian tubes, Gynecologic malignancies, TumorsAbstract
A 33-year-old women with 3 children who has completed child bearing presents to your office for permanent sterilization via a laparoscopic approach. She has recently heard through the internet that removal of the fallopian tubes completely may decrease her ovarian cancer risk more than a tubal ligation with placement of clips or cauterization. She has no family history of gynecologic malignancies but is now curious about preventative measures for ovarian cancer that can decrease her risk. How do you counsel this patient?
References
Hoffman B, Griffith W, Moschos E, et al. Williams Gynecol-ogy. NY, USA: McGraw-Hill; 2012.
Kantarjian HM, Wolf RA. The MD Anderson Manual of Med-ical Oncology. NY, USA: McGraw-Hill; 2016.
Crum CP, Drapkin R, Kindelberger D, Medeiros F, Miron A, Lee Y. Lessons from BRCA: The tubal fimbria emerges as an origin for pelvic serous cancer. Clin Med Res. 2007; 5(1): 35-44. doi: 10.3121/cmr.2007.702
Zweemer RP, van Diest PJ, Verheijen RH, et al. Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations. Gynecol Oncol. 2000; 76(1): 45-50. doi: 10.1006/gyno.1999.5623
Agoff SN, Mendelin JE, Grieco VS, Garcia R. Unexpected gynecologic neoplasms in patients with proven or suspected BRCA-1 or -2 mutations: Implications for gross examina-tion, cytology, and clinical follow-up. Am J Surg Pathol. 2002; 26(2): 171-178. Web site. http://journals.lww.com/ajsp/Ab-stract/2002/02000/Unexpected_Gynecologic_Neoplasms_in_ Patients_With.3.aspx. Accessed August 30, 2016
Colgan TJ, Boerner SL, Murphy J, Cole DE, Narod S, Rosen B. Peritoneal lavage cytology: An assessment of its value during prophylactic oophorectomy. Gynecol Oncol. 2002. 85(3): 397- 403. doi: 10.1006/gyno.2002.6638
Kindelberger DW, Lee Y, Miron A, et al. Intraepithelial carci-noma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am J Surg Pathol. 2007; 31(2): 161-169. doi: 10.1097/01.pas.0000213335.40358.47
Ness RB, Cottreau C. Possible role of ovarian epithelial in-flammation in ovarian cancer. J Natl Cancer Inst. 1999; 91(17): 1459-1467. doi: 10.1093/jnci/91.17.1459
Sieh W, Salvador S, McGuire V, et al. Tubal ligation and risk of ovarian cancer subtypes: A pooled analysis of case-control studies. Int J Epidemiol. 2013. 42(2): 579-589. doi: 10.1093/ije/ dyt042
Woodruf JD. The pathogenesis of ovarian neoplasia. Johns Hopkins Med J. 1979. 144(4): 117-120. Web site. http://euro-pepmc.org/abstract/med/374819. Accessed August 30, 2016
Madsen C, Baandrup L, Dehlendorff C, Kjaer SK. Tubal liga-tion and salpingectomy and the risk of epithelial ovarian cancer and borderline ovarian tumors: A nationwide case-control study. Acta Obstet Gynecol Scand. 2015; 94(1): 86-94. doi: 10.1111/ aogs.12516
Lessard-Anderson CR, Handlogten KS, Molitor RJ, et al. Effect of tubal sterilization technique on risk of serous epithe-lial ovarian and primary peritoneal carcinoma. Gynecol Oncol. 2014; 135(3): 423-427. doi: 10.1016/j.ygyno.2014.10.005
Falconer H, Lin Y, Gronberg H, Altman D. Ovarian cancer risk after salpingectomy: A nationwide population-based study. J Natl Cancer Inst. 2015; 107(2). doi: 10.1093/jnci/dju410
McAlpine JN, Hanley GE, Woo MM, et al. Opportunistic salpingectomy: Uptake, risks, and complications of a regional initiative for ovarian cancer prevention. Am J Obstet Gynecol. 2014; 210(5): 471 e1-e11. doi: 10.1016/j.ajog.2014.01.003
Findley AD, Siedhoff MT, Hobbs KA, et al. Short-term ef-fects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: A pilot randomized controlled trial. Fertil Steril. 2013. 100(6): 1704-1708. doi: 10.1016/j.fertnstert.2013.07.1997
Morelli M, Venturella R, Mocciaro R, et al. Prophylactic salpingectomy in premenopausal low-risk women for ovarian cancer: Primum non nocere. Gynecol Oncol. 2013; 129(3): 448- 451. doi: 10.1016/j.ygyno.2013.03.023
Kwon JS, McAlpine JN, Hanley GE, et al. Costs and benefits of opportunistic salpingectomy as an ovarian cancer prevention strategy. Obstet Gynecol. 2015. 125(2): 338-345. doi: 10.1097/ AOG.0000000000000630
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in Surgical Research (SR) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.