Mechanistic Understanding of Antioxidants Impact on Cognitive Function in Geriatric Canines

Crossmark: check for updates

Authors

  • Lauren R. Thomas Department of Animal Science, University of Arkansas, Fayetteville, AR 72701, USA
  • Hayley A. Booth Department of Animal Science, University of Arkansas, Fayetteville, AR 72701, USA
  • Kaleigh E. Beane Department of Human Environmental Science, University of Arkansas, Fayetteville, AR 72701, USA
  • Kristopher A. Bottoms Department of Animal Science, University of Arkansas, Fayetteville, AR 72701, USA
  • Sami Dridi Department of Poultry Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA

DOI:

https://doi.org/10.17140/aftnsoj-4-e014

Abstract

Canine cognitive dysfunction syndrome (CDS) is a collection of symptoms, or behavioral changes, described specifically in dogs of advanced age unrelated to any other diagnosable ill-ness. Symptoms may include an altered sleep-wake cycle, newly developed destructive behavior, inappropriate elimination, excessive vocalization, pacing or wandering, and altered social interaction with the owner.

References

Roudebush P, Zicker SC, Cotman CW, et al. Nutritional management of brain aging in dogs. J Am Vet Med Assoc. 2005; 227(5): 722-728. doi: 10.2460/javma.2005.227.722

Neilson JC, Hart BL, Cliff KD, Ruehl WW. Prevalence of behavioral changes associated with age-related cognitive impairment in dogs. J Am Vet Med Assoc.. 2001; 218: 1787-1791. doi: 10.2460/ javma.2001.218.1787

Bain MJ, Hart BL, Cliff KD, et al. Predicting behavioral changes associated with age-related cognitive impairment in dogs. J Am Vet Med Assoc. 2001; 218(11): 1792-1795. doi: 10.2460/javma.2001.218.1792

Cotman CW, Head E, Muggenburg BA, et al. Brain aging in the canine: A diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging. 2002; 23(5): 809-818. doi: 10.1016/S0197- 4580(02)00073-8

Youssef SA, Capucchio MT, Rofina JE, et al. Pathology of the aging brain in domestic and laboratory animals, and animal models of human neurodegenerative disease. Vet Pathol. 2016; 53(2): 327-348. doi: 10.1177/0300985815623997

Dror Y, Stern F, Gomori MJ. Vitamins in the prevention or delay LR, et al Editorial | Volume 4 | Number 2| Adv Food Technol Nutr Sci Open J. 2018; 4(2): e6-e8. doi: 10.17140/AFTNSOJ-4-e014 of cognitive disability of aging. Curr Aging Sci. 2014; 7(3): 187-213. doi: 10.2174/1874609808666150201214955

Takeuchi Y, Uetsuka K, Murayama M, et al. Complementary distributions of amyloid-β and neprilysin in the brains of dogs and cats. Vet Pathol. 2008; 45(4): 455-466. doi: 10.1354/vp.45-4-455

Czasch S, Paul S, Baumgartner W. A comparison of immunohistochemical and silver staining methods for the detection of diffuse plaques in the aged canine brain. Neurobiol Aging. 2006; 27(2): 293- 305. doi: 10.1016/j.neurobiolaging.2005.02.017

Dickson DW. Neuropathological diagnosis of Alzheimer’s disease: A perspective from longitudinal clinic-pathologic studies. Neurobiol Aging. 1997; 18(4): S21-26. doi: 10.1101/cshperspect. a006189

Tapp DP, Siwak CT, Gao FQ, et al. Frontal lobe volume, function and β-amyloid pathology in a canine model of aging. J Neurosci. 2004; 24(38): 8205-8213. doi: 10.1523/JNEUROSCI.1339-04.2004

Borras D, Ferrer I, Pumarola M. Age-related changes in the brain of dog. Vet Pathol. 1999; 36(3): 202-211. doi: 10.1354/vp.36- 3-202

Head E, Liu J, Hagen T, et al. Oxidative damage increases with age in a canine model of human brain aging. J Neurochem. 2002; 82(2): 375-381. doi: 10.1046/j.1471-4159.2002.00969.x

Aiken C, Kaake R, Wang X, Huang L. Oxidative stress-mediated regulation of proteasome complexes. Mol Cell Proteomics. 2011; 10(5): doi: 10.1074/mcp.M110.006924

DeCoursey T, Ligeti E. Regulation and termination of NADPH oxidase activity. Cell Mol Life Sci. 2005; 62(19-20): 2173-2193. doi: 10.1007/s00018-005-5177-1

Schreck R, Baeuerle P. A role for oxygen radicals as second messengers. Trends Cell Biol. 1991; 1(2-3): 39-42. doi: 10.1016/0962- 8924(91)90072-H

Ignarro L, Cirino G, Casini A, Napoli C. Nitric oxide as a signaling molecule in the vascular system: An Overview. J Cardiovasc Pharmacol. 1999; 34(6): 879-886

Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3): 298-300. doi: 10.1093/ geronj/11.3.298

Nimse SB, Pal D. Free Radicals, natural antioxidants, and their reaction mechanisms. RSC Advances. 2015; 5: 27986-28006. doi: 10.1039/c4ra13315c

Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol. 2009; Submit your article to this journal | https://openventio.org/submit-manuscript/ Editorial | Volume 4 | Number 2| Thomas 7(1): 65-74. doi: 10.2174/157015909787602823

Prescription Diet Canine b/d, Hill’s Pet Nutrition Inc, Topeka, Kansas

Purina Pro Plan Bright Mind Adult 7+, Nestle Purina Petcare Co, St. Louis, Missouri

Padayatty SJ, Katz A, Wang Y, et al. Vitamin C as an antioxidant: Evaluation of its role in disease prevention. J Am Coll Nutr. 2003; 22(1): 18-35. doi: 10.1080/07315724.2003.10719272

Milgram N, Zicker S, Head E, et al. Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol Aging. 2002; 23(5): 737-745. doi: 10.1016/S0197-4580(02)00020-9

Milgram N, Head E, Zicker S, et al. Long-term treatment with antioxidants and a program of behavioral enrichment reduces agedependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol. 2004; 39(5): 753-765. doi: 10.1016/j. exger.2004.01.007

Milgram NW, Head E, Zicker SC, et al. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: A two-year longitudinal study. Neurobiol Aging. 2005; 26(1): 77-90. doi: 10.1016/j.neurobiolaging.2004.02.014

Nippak PM, Mendelson J, Muggenburg B, Milgram NW. Enhanced spatial ability in aged dogs following dietary and behavioral enrichment. Neurobiol Learn Mem. 2007; 87(4): 610-623. doi: 10.1016/j.nlm.2007.01.001

Milgram NW, Head E, Muggenburg B, et al. Landmark discrimination learning in the dog: Effects of age, an antioxidant fortified food, and cognitive strategy. Neurosci Biobehav Rev. 2002; 26(6): 679- 695. doi: 10.1016/S0149-7634(02)00039-8

Siwak CT, Tapp PD, Head E, et al. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry. 2005; 29(3): 461- 469. doi: 10.1016/j.pnpbp.2004.12.011

Head E, Zicker SC. Nutraceuticals, aging, and cognitive dysfunction. Vet Clin North Am Small Anim Pract. 2004; 34(1): 217-228. doi: 10.1016/j.cvsm.2003.09.007

Opii WO, Joshi G, Head E, et al. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to alzheimers disease. Neurobiol Aging. 2008; 29(1): 51-70. doi: 10.1016/j.neurobiolaging.2006.09.012

Snigdha S, Rivera CD, Milgram NW, Cotman CW. Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine. Neurobiol Aging. 2016; 37: 171-178. doi: 10.1016/j.neurobiolaging.2015.09.015 LR, et al e8

Downloads

Published

2018-10-17

How to Cite

Lauren R. Thomas, Hayley A. Booth, Kaleigh E. Beane, Kristopher A. Bottoms, & Sami Dridi. (2018). Mechanistic Understanding of Antioxidants Impact on Cognitive Function in Geriatric Canines. Advances in Food Technology and Nutrition Sciences, 4(2), e6-e8. https://doi.org/10.17140/aftnsoj-4-e014

Issue

Vol. 4 No. 2 (2018): Volume 4 Issue 2 2018

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All content published in Advances in Food Technology and Nutrition Sciences (AFTNS) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.

Most read articles by the same author(s)

<< < 1 2