Leptin Activates NLRP3 Inflammasome-Associated with Type II Diabetes and Obesity

Abstract

Obesity is a major health problem worldwide and is often associated with leptin resistance and inflammation.1 In this editorial, we will briefly describe the leptin system and the (NOD)-like receptor protein 3 (NLRP3) inflammasome and dis-cuss recent discoveries related to their interaction and role in the development of metabolic disease mainly obesity and Time-divi-sion multiplexing (TDM).