Diet-Mediated Dilated Cardiomyopathy in the Canine
DOI:
https://doi.org/10.17140/aftnsoj-9-179Keywords:
Dilated cardiomyopathy (DCM), Cardiomyopathy, Quince Fruit, Grain-free, Nutrition, BaltistanAbstract
Dilated cardiomyopathy (DCM) is a disease of the heart muscle resulting in decreased myocardial function and is the second most common myopathy in canine. Previously, canine dilated cardiomyopathy was considered to be an inherited disease among large and giant breeds, however, recent reports suggest a possible link between certain grain-free diets and this condition. Several investigations into the incidence of this condition in relationship to grain-free diet consumption have been conducted in recent years. The most recent research shows a static overall trend in the incidence of DCM despite a five-fold increase in the sales of grain-free pet foods. Inadequate intake of protein, taurine, and specific sulfur-containing amino acids may have a potential role in the development of DCM, as these nutrients are crucial for cardiac muscle development and function. However, significant research remains to be done on the topic to discern any potential definitive causation.
References
Walker AL, DeFrancesco TC, Bonagura JD, et al. Association cursors (methionine and lysine).3,42 Copper, potassium, thiamine, of diet with clinical outcomes in dogs with dilated cardiomyopathy selenium, and vitamin E deficiencies are also linked to myocarand congestive heart failure. J Vet Cardiol. 2022; 40: 99-109. doi: dial damage, however, further research is required to determine 10.1016/j.jvc.2021.02.001 a connection.3 Although non-essential, taurine is an important sulfur-containing amino acid that largely affects the functions of
Smith CE, Parnell LD, Lai C-Q, Rush JE, Freeman LM. Investhe cardiovascular, skeletal, and central nervous systems. Methiotigation of diets associated with dilated cardiomyopathy in dogs nine and cysteine are sulfur containing amino acids that form the using foodomics analysis. Scientific Reports. 2021; 11: 15881. doi: non-essential amino acid, taurine.43 The bioavailability of these 10.1038/s41598-021-94464-2 precursors can affect the endogenous synthesis of taurine in the liver.43 Another important nutrient to consider is carnitine. De-
McCauley SR, Clark SD, Quest BW, Streeter RM, Oxford EM. Reficiencies in taurine and carnitine have been shown to be corview of canine dilated cardiomyopathy in the wake of diet-associat-Mini Review | Volume 9 | Number 1 | Ramser A, et al Adv Food Technol Nutr Sci Open J. 2023; 9(1): 6-10. doi: 10.17140/AFTNSOJ-9-179 ed concerns. J Anim Sci. 2020; 98: skaa155. doi: 10.1093/jas/skaa155
Dutton E, López-Alvarez J. An update on canine cardiomyopathies-is it all in the genes? J Small Anim Pract. 2018. doi: 10.1111/ jsap.12841
Bakke AM, Wood J, Salt C, et al. Correction: Responses in randomised groups of healthy, adult Labrador retrievers fed grain-free diets with high legume inclusion for 30 days display commonalities with dogs with suspected dilated cardiomyopathy. BMC Vet Res. 2022; 18: 185. doi: 10.1186/s12917-022-03291-8
Kaplan JL, Stern JA, Fascetti AJ, et al. Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets. PLoS One. 2018; 13: e0209112. doi: 10.1371/journal.pone.0209112
Burns KM. Grain-Free Diets and Dilated Cardiomyopathy. https://todaysveterinarynurse.com/nutrition/grain-free-diets-and-dilated-cardiomyopathy/. Accessed January 25, 2023
Lichtenberger J. Grain-free diets and dilated cardiomyopathy, an emerging problem? Paper presented at: the 2019 OVMA (Ontario Veterinary Medical Association) Conference; January 31, 2019 to February 2, 2019; Toronto, Canada. 118-120
Gaar-Humphreys KR, Spanjersberg TC, Santarelli G, et al. Genetic basis of dilated cardiomyopathy in dogs and its potential as a bidirectional model. Animals (Basel). 2022; 12: 1679. doi: 10.3390/ ani12131679
Freeman LM, Stern JA, Fries R, Adin DB, Rush JE. Diet-associated dilated cardiomyopathy in dogs: what do we know? J Am Vet Med Assoc. 2018; 253: 1390-1394. doi: 10.2460/javma.253.11.1390
Vollmar A. The prevalence of cardiomyopathy in the Irish wolfhound: A clinical study of 500 dogs. J Am Anim Hosp Assoc. 2000; 36: 125-132. doi: 10.5326/15473317-36-2-125
Saito T, Suzuki R, Yuchi Y, Yasumura Y, Teshima T, Matsumoto H, Koyama H. A case of a small-breed dog with diet-related dilated cardiomyopathy showing marked improvements in cardiac morphology and function after dietary modification. Vet Sci. 2022; 9: 593. doi: 10.3390/vetsci9110593
Adin D, Freeman L, Stepien R, et al. Effect of type of diet on blood and plasma taurine concentrations, cardiac biomarkers, and echocardiograms in 4 dog breeds. J Vet Inter Med. 2021; 35: 771- 779. doi: 10.1111/jvim.16075
Quest BW, Clark SD, Garimella S, Konie A, Leach SB, Oxford EM. Incidence of canine dilated cardiomyopathy, breed and age distributions, and grain-free diet sales in the United States from 2000-2019: A retrospective survey. Front Anim Sci. 2020; 3. doi: 10.1101/2020.09.27.315770
U. S. Food and Drug Administration (FDA). Investigation into Potential Link between Certain Diets and Canine Dilated Cardiomyopathy. https://www.fda.gov/animal-veterinary/ 9 Ramser outbreaks-and-advisories/fda-investigation-potential-link-between-certain-diets-and-canine-dilated-cardiomyopathy. Accessed January 25, 2023
Bellumori TP, Famula TR, Bannasch DL, Belanger JM, Oberbauer AM. Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc. 2013; 242: 1549-1555. doi: 10.2460/javma.242.11.1549
Fioretti M, Delli C. Epidemiological survey of dilatative cardiomyopathy in dogs. Veterinaria. 1988; 2: 1
Dukes-McEwan J, Borgarelli M, Tidholm A, Vollmar AC, Häggström J. Proposed guidelines for the diagnosis of canine idiopathic dilated cardiomyopathy. J Vet Cardiol. 2003; 5: 7-19. doi: 10.1016/s1760-2734(06)70047-9
Smith CE, Parnell LD, Lai CQ, et al. Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls. Sci Rep. 2022; 12: 22585. doi: 10.1038/s41598-022-26322-8
Koch J, Pedersen HD, Jensen AL, Flagstad A. M-mode echocardiographic diagnosis of dilated cardiomyopathy in giant breed dogs. Zentralbl Veterinarmed A. 1996; 43: 297-304. doi: 10.1111/ j.1439-0442.1996.tb00456.x
Wess G. Screening for dilated cardiomyopathy in dogs. J Vet Cardiol. 2022; 40: 51-68. doi: 10.1016/j.jvc.2021.09.004
Ward J, Ware W, Viall A. Association between atrial fibrillation and right-sided manifestations of congestive heart failure in dogs with degenerative mitral valve disease or dilated cardiomyopathy. J Vet Cardiol. 2019; 21: 18-27. doi: 10.1016/j.jvc.2018.10.006
Tidholm A, Jönsson L. Histologic characterization of canine dilated cardiomyopathy. Vet Pathol. 2005; 42: 1-8. doi: 10.1354/ vp.42-1-1
Guglielmini C. Cardiovascular diseases in the ageing dog: Diagnostic and therapeutic problems. Vet Res Commun. 2003; 27: 555- 560. doi: 10.1023/b:verc.0000014216.73396.f6
Thomas DE, Wheeler R, Yousef ZR, Masani ND. The role of echocardiography in guiding management in dilated cardiomyopathy. Eur J Echocardiogr. 2009; 10: iii15-iii21. doi: 10.1093/ejechocard/jep158
Schober K, Hart T, Stern JA, et al. Detection of congestive heart failure in dogs by Doppler echocardiography. J Vet Intern Med. 2010; 24: 1358-1368. doi: 10.1111/j.1939-1676.2010.0592.x
Petrie J-P. Practical application of holter monitoring in dogs and cats. Clin Tech Small Anim Pract. 2005; 20(3): 173-181. doi: 10.1053/j.ctsap.2005.05.006
Martin MWS, Stafford Johnson MJ, Celona B. Canine dilated cardiomyopathy: A retrospective study of signalment, presentation A, et al Mini Review | Volume 9 | Number 1 | Adv Food Technol Nutr Sci Open J. 2023; 9(1): 6-10. doi: 10.17140/AFTNSOJ-9-179 and clinical findings in 369 cases. J Small Anim Pract. 2009; 50: 23- doi: 10.1111/j.1748-5827.2008.00659.x 29. Bonagura JD, Visser LC. Echocardiographic assessment of dilated cardiomyopathy in dogs. J Vet Cardiol. 2022; 40: 15-50. doi: 10.1016/j.jvc.2021.08.004
Morgan RV. Handbook of Small Animal Practice. 3rd ed. Philadelphia, USA: Saunders; 1997
Singletary, G.E, Morris, N.A, Lynne O'Sullivan, M, Gordon, S.G, Oyama, M.A. Prospective evaluation of NT-proBNP assay to detect occult dilated cardiomyopathy and predict survival in doberman pinschers. J Vet Intern Med. 2012; 26: 1330-1336. doi: 10.1111/j.1939-1676.2012.1000.x
Langhorn R, Willesen JL. Cardiac troponins in dogs and cats. J Vet Intern Med. 2016; 30: 36-50. doi: 10.1111/jvim.13801
Adin D, DeFrancesco TC, Keene B, et al. Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type. J Vet Cardiol. 2019; 21: 1-9. doi: 10.1016/j.jvc.2018.11.002
Banton S, Baynham A, Pezzali JG, von Massow M, Shoveller AK. Grains on the brain: A survey of dog owner purchasing habits related to grain-free dry dog foods. PLoS One. 2021; 16: e0250806. doi: 10.1371/journal.pone.0250806
Shalamoff A, Claremont C, Miller C, Neiman N. Kibble me this: The scientific and cultural debate over boutique, exotic, and grain-free canine nutrition. 2019. https://core.ac.uk/download/ pdf/289019761.pdf. Accessed January 25, 2023
Dunn S. Development and Management of Canine Adverse Food Reactions and its Connections to the Grain-Free Dog Food Movement. 2020. https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=2020&context=honors. Accessed January 25, 2023
Ontiveros ES, Whelchel BD, Yu J, et al. Development of plasma and whole blood taurine reference ranges and identification of dietary features associated with taurine deficiency and dilated cardiomyopathy in golden retrievers: A prospective, observational study. PLoS One. 2020; 15: e0233206. doi: 10.1371/journal. Submit your article to this journal | https://openventio.org/submit-manuscript/ Mini Review | Volume 9 | Number 1 | Ramser pone.0233206
Wilfart A, Montagne L, Simmins PH, van Milgen J, Noblet J. Sites of nutrient digestion in growing pigs: Effect of dietary fiber. J Anim Sci. 2007; 85: 976-983. doi: 10.2527/jas.2006-431
Twomey LN, Pethick DW, Choct M, et al. The use of exogenous feed enzymes in reducing the anti-nutritive effects on dietary fibre in dog foods. Recent Advances in Animal Nutrition. 2001; 13: 179-186
Ko KS, Fascetti AJ. Dietary beet pulp decreases taurine status in dogs fed low protein diet. J Anim Sci Technol. 2016; 58: 29. doi: 10.1186/s40781-016-0112-6
Sanderson SL, Gross KL, Ogburn PN, et al. Effects of dietary fat and L-carnitine on plasma and whole blood taurine concentrations and cardiac function in healthy dogs fed protein-restricted diets. Am J Vet Res. 2001; 62: 1616-1623. doi: 10.2460/ ajvr.2001.62.1616
Basili M, Pedro B, Hodgkiss-Geere H, Navarro-Cubas X, Graef N, Dukes-McEwan J. Low plasma taurine levels in English cocker spaniels diagnosed with dilated cardiomyopathy. Journal of Small Animal Practice. 2021; 62: 570-579. doi: 10.1111/jsap.13306
Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992; 72: 101-163. doi: 10.1152/physrev.1992.72.1.101
Sanderson SL. Taurine and carnitine in canine cardiomyopathy. Vet Clin North Am Small Anim Pract. 2006; 36: 1325-1343, vii-viii. doi: 10.1016/j.cvsm.2006.08.010
Keene B, Panciera D, Atkins C, Regitz V, Schmidt M, Shug A. Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy. J Am Vet Med Assoc. 1991; 198: 647-650
Neumann S, Welling H, Thuere S, Kaup FJ. Plasma L-carnitine concentration in healthy dogs and dogs with hepatopathy. Vet Clin Pathol. 2007; 36: 137-140. doi: 10.1111/j.1939-165x.2007.tb00199.x
Rizos I. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration. Am Heart J. 2000; 139: S120-S123. doi: 10.1067/mhj.2000.103917 A, et al 10
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