Comparative Evaluation of Ultrasound-Guided Peripheral Nerve Blocks in Elective Orthopedic Procedures
DOI:
https://doi.org/10.17140/aoj.2021.v1.i01.pp01-07.2697Keywords:
ultrasound-guided nerve block, regional anesthesia, orthopedic surgery, adductor canal block, interscalene blockAbstract
Ultrasound guidance has, over the last two decades, displaced peripheral nerve stimulation and landmark-based technique as the dominant method for placing peripheral nerve blocks in elective orthopedic surgery, on the strength of direct visualization of the target nerve, the spread of local anesthetic, and adjacent vascular structures. This review synthesizes the comparative evidence for ultrasound-guided peripheral nerve blockade across the elective orthopedic procedures in which it is now most established: upper-limb interscalene and supraclavicular blocks for shoulder arthroscopy and arthroplasty, femoral and adductor canal blocks for total knee arthroplasty, and popliteal sciatic blocks for foot and ankle surgery. Randomized and meta-analytic data indicate that ultrasound guidance reduces block failure and vascular puncture relative to nerve-stimulator technique, while adductor canal block preserves quadriceps strength and reduces fall risk relative to femoral nerve block after total knee arthroplasty without sacrificing analgesic efficacy. Continuous perineural catheter techniques extend these benefits into the ambulatory and early postoperative period, and current practice increasingly treats peripheral nerve stimulation as an adjunct confirmatory tool rather than a primary localization method once ultrasound is available. We conclude that site-specific selection among ultrasound-guided techniques, rather than a single default approach, is what the comparative literature actually supports for elective orthopedic practice, and we identify where the evidence base for newer fascial-plane alternatives remains comparatively thin.
References
Abrahams MS, Aziz MF, Fu RF, Horn JL (2009) Ultrasound guidance compared with electrical neurostimulation for peripheral nerve block: a systematic review and meta-analysis of randomized controlled trials. British Journal of Anaesthesia, 102(3):408-417, DOI:10.1093/bja/aen384.
Munirama S, McLeod G (2015) A systematic review and meta-analysis of ultrasound versus electrical stimulation for peripheral nerve location and blockade. Anaesthesia, DOI:10.1111/anae.13098.
Gadsden J (2021) The role of peripheral nerve stimulation in the era of ultrasound-guided regional anaesthesia. Anaesthesia, DOI:10.1111/anae.15257.
Incidence of intraneural needle insertion in ultrasound-guided femoral nerve block: a comparison between the out-of-plane versus the in-plane approaches (2014) Revista Espanola de Anestesiologia y Reanimacion, PMID:24314696.
Melnyk M, Ibinson JW, Kentor ML, Orebaugh SL (2018) Updated Retrospective Single-Center Comparative Analysis of Peripheral Nerve Block Complications Using Landmark Peripheral Nerve Stimulation Versus Ultrasound Guidance as a Primary Means of Nerve Localization. Journal of Ultrasound in Medicine, DOI:10.1002/jum.14603.
Fredrickson MJ, Kilfoyle DH (2009) Neurological complication analysis of 1000 ultrasound guided peripheral nerve blocks for elective orthopaedic surgery: a prospective study. Anaesthesia, DOI:10.1111/j.1365-2044.2009.05938.x.
Barrington MJ, Kluger R (2013) Incidence of local anesthetic systemic toxicity and postoperative neurologic symptoms associated with 12,668 ultrasound-guided nerve blocks: an analysis from a prospective clinical registry. Regional Anesthesia and Pain Medicine, PMID:22705953.
Macfarlane AJR, Gitman M, Bornstein KJ, El-Boghdadly K, Weinberg G (2021) Updates in our understanding of local anaesthetic systemic toxicity: a narrative review. Anaesthesia, DOI:10.1111/anae.15282.
Kilicaslan A, et al. (2014) Ultrasound-Guided Multiple Peripheral Nerve Blocks in a Superobese Patient. Case Reports in Anesthesiology, DOI:10.1155/2014/896914.
A Double-Blind Comparison of Ropivacaine, Bupivacaine, and Mepivacaine During Sciatic and Femoral Nerve Blockade (1998) Anesthesia & Analgesia, PMID:9728836.
Ropivacaine versus levobupivacaine in peripheral nerve block: A PRISMA-compliant meta-analysis of randomized controlled trials (2017) Medicine, PMID:28383425.
Comparison of the onset time between 0.375% ropivacaine and 0.25% levobupivacaine for ultrasound-guided infraclavicular brachial plexus block: a randomized-controlled trial (2021) Scientific Reports, DOI:10.1038/s41598-021-84172-2.
Wang D, et al. (2017) Adductor canal block versus femoral nerve block for total knee arthroplasty: a meta-analysis of randomized controlled trials. Scientific Reports, 7:40721, DOI:10.1038/srep40721.
Ultrasound-guided genicular nerve blocks following total knee arthroplasty: a randomized, double-blind, placebo-controlled trial (2021) PMID:34261807.
Analgesic efficacy of ultrasound-guided genicular nerve block in combination with adductor canal block in total knee arthroplasty: A randomised, double-blind, placebo-controlled trial (2025) PMID:40979775.
Comparison of ultrasound-guided genicular nerve block and knee periarticular infiltration for postoperative pain and functional outcomes in knee arthroplasty - A randomised trial (2024) PMID:38044925.
Liposomal bupivacaine versus ropivacaine in four-in-one nerve block for total knee arthroplasty: a randomized controlled trial (2026) BMC Anesthesiology, DOI:10.1186/s12871-026-04036-y.
Exsteen OW, Svendsen CN, Rothe C, Lange KHW, Lundstrom LH (2022) Ultrasound-guided peripheral nerve blocks for preoperative pain management in hip fractures: a systematic review. BMC Anesthesiology, 22:192, DOI:10.1186/s12871-022-01720-7.
Ultrasound-guided supra-inguinal fascia iliaca compartment block for older adults admitted to the emergency department with hip fracture: a randomized controlled, double-blind clinical trial (2021) BMC Geriatrics, DOI:10.1186/s12877-021-02646-4.
Ultrasound-guided continuous fascia iliaca compartment block for pre-operative pain control in very elderly patients with hip fracture: A randomized controlled trial (2018) PMID:30186422.
Effect of perioperative ultrasound guided fascia iliaca compartment block in elderly adults with hip fractures undergoing arthroplasty in spinal anesthesia-a randomized controlled trial (2023) PMID:36732687.
Efficacy of Ultrasound-Guided Pericapsular Nerve Group (PENG) Block Combined With Local Infiltration Analgesia on Postoperative Pain After Total Hip Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial (2022) The Journal of Arthroplasty.
Pericapsular nerve group block in hip arthroplasty: A prospective randomized trial (2023) PMID:37644789.
Comparison between the ultrasound guided pericapsular nerve group block and anterior quadratus lumborum block in elderly patients undergoing total hip replacement surgeries: a randomized controlled clinical trial (2025) PMID:40762162.
Ilfeld BM, et al. (2016) Continuous Popliteal Sciatic Blocks: Does Varying Perineural Catheter Location Relative to the Sciatic Bifurcation Influence Block Effects? A Dual-Center, Randomized, Subject-Masked, Controlled Clinical Trial. Anesthesia & Analgesia, DOI:10.1213/ANE.0000000000001211.
Ilfeld BM (2011) Continuous peripheral nerve blocks in the hospital and at home. Anesthesiology Clinics, PMID:21620338.
Hade AD, Okano S, Pelecanos A, Chin A (2021) Factors associated with low levels of patient satisfaction following peripheral nerve block. Anaesthesia and Intensive Care, DOI:10.1177/0310057X20972404.
Efficacy of perineural versus intravenous dexamethasone in prolonging the duration of analgesia when administered with peripheral nerve blocks: a systematic review and meta-analysis (2022) systematic review and meta-analysis.
Intravenous dexamethasone and peripheral nerve blocks: A systemic review and meta-analysis of randomized controlled trials (2020) Saudi Journal of Anaesthesia.
Factors associated with rebound pain after peripheral nerve block for ambulatory surgery (2021) British Journal of Anaesthesia.
Prophylactic interventions to prevent rebound pain after peripheral nerve block in adults: a systematic review and network meta-analysis of randomised controlled trials (2026) PMID:42187168.
Comparison of Ultrasound-Guided Lumbar Erector Spinae Plane Block and Transmuscular Quadratus Lumborum Block for Postoperative Analgesia in Hip and Proximal Femur Surgery (2018) Anesthesia: Essays and Researches, DOI:10.4103/aer.aer_142_18.
Comparison of the analgesic effects of ultrasound-guided erector spinae plane block and quadratus lumborum block: a systematic review and meta-analysis (2025) systematic review and meta-analysis.
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