Dosimetric Characterization of an Abscopal Response in a Patient With Oligometastatic Melanoma Undergoing Concurrent Treatment With Pembrolizumab and Stereotactic Body Radiotherapy (SBRT)
DOI:
https://doi.org/10.17140/CSMMOJ-4-121Keywords:
Stereotactic body radiotherapy (SBRT), Dosimetric, Immunotherapy, RadiationAbstract
Recently, preclinical and clinical evidence has shown that a synergy may exist between radiation and immune check-point therapies
such as pembrolizumab. Radiation has been shown to activate the immune system, and in combination with immunotherapy may
lead to systemic anti-tumor responses. However, the exact dose regimens needed to induce synergistic responses are unclear. Here,
we report a dosimetric characterization of a patient treated with stereotactic radiation in combination with immune check-point
therapy.
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