Cancer Disease-Oriented-Drug Development Examples

Authors

  • Daniel Gandia Universidad de Buenos Aires–Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Exactas y Naturales, Instituto de Física del Plasma, Buenos Aires, Argentina
  • Cecilia Suarez Universidad de Buenos Aires–Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Exactas y Naturales, Instituto de Física del Plasma, Buenos Aires, Argentina

DOI:

https://doi.org/10.17140/CSMMOJ-7-132

Keywords:

Cancer, Neoplasms, Chemotherapy, Antitumor agents, Drug development

Abstract

The history of cancer medical treatments goes up to 1908 with the use of arsenic in this disease. An intermediate milestone was
the discovery, in 1943, of an amazing tumor response using nitrogen mustard in a patient with a radio-resistant lymphoma. Chemotherapy
really born with this achievement, and a plethora of antitumor agent’s came to age after 1948 till nowadays. Here, some
examples of recent disease-oriented drug development approaches are presented and analyzed, as well as present limitations and
challenges raised by each one.

References

DeVita VJr., Lawrence T, Rosenberg S. Cancer, Principles & Prac-tice of Oncology. 11th ed. PA, USA: Wolters Kluver; 2019: 297-311.

Lietman CD, Johnson ML, McCormick F, Lindsay CR. More to the RAS story: KRAS G12C inhibition, resistance mechanisms and moving beyond KRAS G12C. Am Soc Clin Oncol Educ Book. 2022; 42: 1-13. doi: 10.1200/EDBK_351333

Stalnecker CA, Der CJ. RAS, wanted dead or alive: Advances in targeting RAS mutant cancers. Sci Signal. 2020; 13: eeay6013. doi: 10.1126/scisignal.aay6013

Schmid P, Cortes J, Dent R, et al. Event-free survival with Pem-brolizumab in early triple-negative breast cancer. N Eng J Med. 2022; 386: 556-567. doi: 10.1056/NEJMoa2112651

Cortés–Guiral D, Hübner M, Alyami M, et al. Primary and met-astatic peritoneal surface malignancies. Nat Rev Dis Prim. 2021; 7: 91. doi: 10.1038/s41572-021-00326-6

No authors listed. On-target BTK mutations promote resis-tance to noncovalent BTK inhibitors. Cancer Discov. 2022; 12(5): 1179. doi: 10.1158/2159-8290.CD-RW2022-041 Opinion | Volume 7 | Number 1|

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Published

2022-10-18

How to Cite

Daniel Gandia, & Cecilia Suarez. (2022). Cancer Disease-Oriented-Drug Development Examples. Cancer Studies and Molecular Medicine , 7(1), 1–2. https://doi.org/10.17140/CSMMOJ-7-132

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