The Emerging Spectrum of Early Life Exposure-Related Inflammation and Epigenetic Therapy
DOI:
https://doi.org/10.17140/CSMMOJ-4-125Keywords:
Early life exposure, Environmental factors, Inflammation, Uterine fibroids, Epigenetic modifiersAbstract
Early life exposure to a variety of insults during sensitive windows of development can reprogram normal physiological responses and
alter disease susceptibility later in life. During this process, inflammation triggered by a variety of adverse exposures plays an important
role in the initiation and development of many types of diseases including tumorigenesis. This systematic review article summaries
the current knowledge about the role and mechanism of inflammation in development of diseases. In addition, epigenome alteration
related to inflammation and treatment options using epigenetic modifiers are highlighted and discussed.
References
Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: Importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol. 2007; 147(2): 227- 235. doi: 10.1111/j.1365-2249.2006.03261.x
Diakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-relat-ed inflammation and treatment effectiveness. Lancet Oncol. 2014; 15(11): e493-e503. doi: 10.1016/S1470-2045(14)70263-3
Crusz SM, Balkwill FR. Inflammation and cancer: Advances and new agents. Nat Rev Clin Oncol. 2015; 12(10): 584-596. doi: 10.1038/nrclinonc.2015.105
Lee H, Abston E, Zhang D, Rai A, Jin Y. Extracellular vesicle: An emerging mediator of intercellular crosstalk in lung inflam-mation and injury. Front Immunol. 2018; 9: 924. doi: 10.3389/fim-mu.2018.00924
Kunnumakkara AB, Sailo BL, Banik K, et al. Chronic diseas-es, inflammation, and spices: How are they linked? J Transl Med. 2018; 16(1): 14. doi: 10.1186/s12967-018-1381-2
Leonardi GC, Accardi G, Monastero R, Nicoletti F, Libra M. Ageing: From inflammation to cancer. Immun Ageing. 2018; 15: 1. doi: 10.1186/s12979-017-0112-5
Mantovani A. The inflammation - cancer connection. FEBS J. 2018; 285(4): 638-640. doi: 10.1111/febs.14395
Martinez BK, White CM. The Emerging role of inflammation in cardiovascular disease. Ann Pharmacother. 2018; 52(8): 801-809. doi: 10.1177/1060028018765939
Castaneda S, Gonzalez-Juanatey C, Gonzalez-Gay MA. Inflam-mation and heart diseases. Curr Pharm Des. 2018; 24(3): 262-280. doi: 10.2174/1381612824666180123102632
Wu Y, Dong Y, Duan S, Zhu D, Deng L. Metabolic syn-drome, inflammation, and cancer. Mediators Inflamm. 2017; doi: Systematic Review | Volume 4 | Number 1| Yang Q, et al 10.1155/2017/8259356
Juergens RA, Wrangle J, Vendetti FP, et al. Combination epi-genetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov. 2011; 1(7): 598-607. doi: 10.1158/2159-8290.CD-11-0214
Al-Talabany S, Mordi I, Graeme Houston J, et al. Epicardial adipose tissue is related to arterial stiffness and inflammation in patients with cardiovascular disease and type 2 diabetes. BMC Car-diovasc Disord. 2018; 18(1): 31. doi: 10.1186/s12872-018-0770-z
Chen X, Chen X, Xu Y, et al. Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease. Hum Genomics. 2016; 10(2): 21. doi: 10.1186/s40246-016-0067-1
Yang Q, Diamond MP, Al-Hendy A. Early life adverse envi-ronmental exposures increase the risk of uterine fibroid develop-ment: Role of Epigenetic Regulation. Front Pharmacol. 2016; 7: 40. doi: 10.3389/fphar.2016.00040
Cook JD, Davis BJ, Cai SL, et al. Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance. Proc Natl Acad Sci U S A 2005; 102(24): 8644-8649. doi: 10.1073/pnas.0503218102
Du Preez A, Leveson J, Zunszain PA, Pariante CM. Inflamma-tory insults and mental health consequences: Does timing matter when it comes to depression? Psychol Med. 2016; 46(10): 2041- 2057. doi: 10.1017/S0033291716000672
Tartaglione AM, Venerosi A, Calamandrei G. Early-life toxic insults and onset of sporadic neurodegenerative diseases-an over-view of experimental studies. Curr Top Behav Neurosci. 2016; 29: 231-264. doi: 10.1007/7854_2015_416
Spann K, Snape N, Baturcam E, Fantino E. The impact of early-life exposure to air-borne environmental insults on the function of the airway epithelium in asthma. Ann Glob Health. 2016; 82(1): 28-40. doi: 10.1016/j.aogh.2016.01.007
Ley D, Desseyn JL, Mischke M, et al. Early-life origin of intes-tinal inflammatory disorders. Nutr Rev. 2017; 75(3): 175-187. doi: 10.1093/nutrit/nuw061
Olvera Alvarez HA, Kubzansky LD, Campen MJ, Slavich GM. Early life stress, air pollution, inflammation, and disease: An in-tegrative review and immunologic model of social-environmental adversity and lifespan health. Neurosci Biobehav Rev. 2018; 92: 226- 242. doi: 10.1016/j.neubiorev.2018.06.002
Challier JC, Basu S, Bintein T, et al. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta. 2008; 29(3): 274-281. doi: 10.1016/j.placen-ta.2007.12.010
Armitage JA, Poston L, Taylor PD. Developmental origins of obesity and the metabolic syndrome: The role of maternal obe-sity. Front Horm Res. 2008; 36: 73-84. doi: 10.1159/0000115355
Dunn GA, Bale TL. Maternal high-fat diet effects on third-generation female body size via the paternal lineage. Endocrinology. 2011; 152(6): 2228-2236. doi: 10.1210/en.2010-1461
Bolton JL, Bilbo SD. Developmental programming of brain and behavior by perinatal diet: Focus on inflammatory mecha-nisms. Dialogues Clin Neurosci. 2014; 16(3): 307-320.
Dahlgren J, Nilsson C, Jennische E, et al. Prenatal cytokine exposure results in obesity and gender-specific programming. Am J Physiol Endocrinol Metab. 2001; 281(2): E326-E334. doi: 10.1152/ ajpendo.2001.281.2.E326
Yang Q, Mas A, Diamond MP, Al-Hendy A. The mechanism and function of epigenetics in uterine leiomyoma development. Reprod Sci. 2016; 23(2): 163-175. doi: 10.1177/1933719115584449
Ng GY, Yun-An L, Sobey CG, et al. Epigenetic regulation of inflammation in stroke. Ther Adv Neurol Disord. 2018; 11: 175. doi: 10.1177/1756286418771815
Ratay ML, Balmert SC, Bassin EJ, Little SR. Controlled re-lease of an HDAC inhibitor for reduction of inflammation in dry eye disease. Acta Biomater. 2018; 71: 261-270. doi: 10.1016/j. actbio.2018.03.002
Tarun A, Antoniades C. The Era of cardiovascular epi-genetics: Histone deacetylases and vascular inflammation. Cardio-vasc Res.2018; 114(7): 928-930. doi: 10.1093/cvr/cvy099
Thankam FG, Boosani CS, Dilisio MF, Agrawal DK. MicroR-NAs associated with inflammation in shoulder tendinopathy and glenohumeral arthritis. Mol Cell Biochem. 2018; 437(1-2): 81-97. doi: 10.1007/s11010-017-3097-7
Wu XM, Ji KQ, Wang HY, et al. MicroRNA-339-3p alleviates inflammation and edema and suppresses pulmonary microvascu-lar endothelial cell apoptosis in mice with severe acute pancreati-tis-associated acute lung injury by regulating Anxa3 via the Akt/ mTOR signaling pathway. J Cell Biochem. 2018; 119(8): 6704-6714. doi: 10.1002/jcb.26859
Xia M, Xu H, Dai W, et al. The role of HDAC2 in cigarette smoke-induced airway inflammation in a murine model of asth-ma and the effect of intervention with roxithromycin. J Asthma. 2018; 55(4): 337-344. doi: 10.1080/02770903.2017.1337788
Yang J, Tian B, Brasier AR. Targeting chromatin remodeling in inflammation and fibrosis. Adv Protein Chem Struct Biol. 2017; 107: 1-36. doi: 10.1016/bs.apcsb.2016.11.001
Li H, Yao Q, Mariscal AG, et al. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflam-mation. Nat Commun. 2018; 9(1): 1420. doi: 10.1038/s41467-018- 20 Yang Q, et al 03704-z
Lu L, Claud EC. Intrauterine inflammation, epigenetics, and microbiome influences on preterm infant health. Curr Pathobiol Rep. 2018; 6(1): 15-21. doi: 10.1007/s40139-018-0159-9
Wang Q, Trevino LS, Wong RL, et al. Reprogramming of the epigenome by MLL1 links early-life environmental exposures to prostate cancer risk. Mol Endocrinol. 2016; 30(8): 856-871. doi: 10.1210/me.2015-1310
Jorgensen EM, Alderman MH, Taylor HS. Preferential epi-genetic programming of estrogen response after in utero xenoes-trogen (bisphenol-A) exposure. FASEB J. 2016; 30(9): 3194-3201. doi: 10.1096/fj.201500089R
Yang Q, Al-Hendy A. Developmental environmental expo-sure alters the epigenetic features of myometrial stem cells. Gy-necol Obstet Res. 2016; 3(2): e1-e4. doi: 10.17140/GOROJ-3-e005
Monica F, Elisa P, Caterina S, et al. Changes of intestinal mi-crobiota in early life. J Matern Fetal Neonatal Med. 2018; 10: 1-8. doi: 10.1080/14767058.2018.1506760
Park CH, Eun CS, Han DS. Intestinal microbiota, chronic in-flammation, and colorectal cancer. Intest Res. 2018; 16(3): 338-345. doi: 10.5217/ir.2018.16.3.338
Huh JW, Laurer HL, Raghupathi R, Helfaer MA, Saatman KE. Rapid loss and partial recovery of neurofilament immunostaining following focal brain injury in mice. Exp Neurol. 2002, 175(1): 198-208. doi: 10.1006/exnr.2002.7880
Weaver IC, Cervoni N, Champagne FA, et al. Epigenetic pro-gramming by maternal behavior. Nat Neurosci. 2004, 7(8): 847- 854. doi: 10.1038/nn1276
Sabry M, Al-Hendy A. Medical treatment of uterine leiomyoma. Reprod Sci. 2012, 19(4): 339-353. doi: 10.1177/1933719111432867
Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F. Epide-miology and risk factors of uterine fibroids. Best Pract Res Clin Ob-stet Gynaecol. 2018; 46: 3-11. doi: 10.1016/j.bpobgyn.2017.09.004
Bulun SE. Uterine fibroids. N Engl J Med. 2013; 369(14): 1344- 55. doi: 10.1056/NEJMra1209993
Ono M, Qiang W, Serna VA, et al. Role of stem cells in hu-man uterine leiomyoma growth. PLoS One. 2012; 7(5): e36935. doi: 10.1371/journal.pone.0036935
Bulun SE, Moravek MB, Yin P, et al. Uterine leiomyoma stem cells: Linking progesterone to growth. Semin Reprod Med. 2015; 33(5): 357-365. doi: 10.1055/s-0035-1558451
Mas A, Nair S, Laknaur A, et al. Stro-1/CD44 as putative hu-man myometrial and fibroid stem cell markers. Fertil Steril. 2015; 104(1): 225-234. doi: 10.1016/j.fertnstert.2015.04.021 Systematic Review | Volume 4 | Number 1|
Mas A, Stone L, O’Connor PM, et al. Developmental expo-sure to endocrine disruptors expands murine myometrial stem cell compartment as a prerequisite to leiomyoma tumorigenesis. Stem Cells. 2017, 35(3): 666-678. doi: 10.1002/stem.2519
Alam SR, Stirrat C, Spath N, et al. Myocardial inflammation, injury and infarction during on-pump coronary artery bypass graft surgery. J Cardiothorac Surg. 2017; 12(1): 115. doi: 10.1186/ s13019-017-0681-6
Prusinski Fernung LE, Al-Hendy A, Yang Q: A preliminary study: Human fibroid stro-1(+)/CD44(+) stem cells isolated from uterine fibroids demonstrate decreased DNA repair and genomic integrity compared to adjacent myometrial stro-1(+)/ CD44(+) cells. Reprod Sci. 2018; doi: 10.1177/1933719118783252
Protic O, Toti P, Islam MS, et al. Possible involvement of inflammatory/reparative processes in the development of uter-ine fibroids. Cell Tissue Res. 2016; 364(2): 415-427. doi: 10.1007/ s00441-015-2324-3
Ciebiera M, Wlodarczyk M, Wrzosek M, et al. TNF-alpha serum levels are elevated in women with clinically symptom-atic uterine fibroids. Int J Immunopathol Pharmacol. 2018; 32: 2058738418779461. doi: 10.1177/2058738418779461.
Orciani M, Caffarini M, Biagini A, et al. Chronic inflamma-tion may enhance leiomyoma development by the involvement of progenitor cells. Stem Cells Int. 2018; doi: 10.1155/2018/1716246
Yang Q, Trevino L, EI Andaloussi A, et al. Developmental re-programming of pro-inflammatory pathway mediates adult onset of uterine fibroids. American Society for Reproductive Medcine. 2018.
Sadeghi A, Rostamirad A, Seyyedebrahimi S, Meshkani R. Curcumin ameliorates palmitate-induced inflammation in skeletal muscle cells by regulating JNK/NF-kB pathway and ROS produc-tion. Inflammopharmacology. 2018; doi: 10.1007/s10787-018-0466-0
Wang J, Zhao L, Wei Z, et al. Inhibition of histone deacety-lase reduces lipopolysaccharide-induced-inflammation in primary mammary epithelial cells by regulating ROS-NF-small ka, Cyril-licB signaling pathways. Int Immunopharmacol. 2018, 56: 230-234.
Xu Y, Liu L. Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF-kappaB signaling pathway. Influenza Other Respir Viruses. 2017; 11(5): 457-463. doi: 10.1111/irv.12459
Mishra N, Brown DR, Olorenshaw IM, Kammer GM. Tricho-statin a reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. Proc Natl Acad Sci U S A. 2001; 98(5): 2628-2633. doi: 10.1073/ pnas.051507098
Yang F, Yang Y, Wang Y, et al. Selective class I histone deacety-lase inhibitors suppress persistent spontaneous nociception and Systematic Review | Volume 4 | Number 1| Yang Q, et al thermal hypersensitivity in a rat model of bee venom-induced inflammatory pain. Sheng Li Xue Bao. 2015; 67(5): 447-454.
Heers H, Stanislaw J, Harrelson J, Lee MW. Valproic acid as an adjunctive therapeutic agent for the treatment of breast cancer. Eur J Pharmacol. 2018; 835: 61-74. doi: 10.1016/j.ejphar.2018.07.057
Hajmirza A, Emadali A, Gauthier A, et al. BET family protein BRD4: An emerging actor in NFkappaB signaling in inflamma-tion and cancer. Biomedicines. 2018; 6(1): E16. doi: 10.3390/bio-medicines6010016
Shi J, Vakoc CR. The mechanisms behind the therapeutic ac-tivity of BET bromodomain inhibition. Mol Cell. 2014; 54(5): 728- 36. doi: 10.1016/j.molcel.2014.05.016
Mertz JA, Conery AR, Bryant BM, et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci U S A. 2011; 108(40): 16669-16674. doi: 10.1073/ pnas.1108190108
Chatterjee N, Bohmann D. BET-ting on Nrf2: How Nrf2 signaling can influence the therapeutic activities of BET pro-tein inhibitors. Bioessays. 2018, 40(5): e1800007. doi: 10.1002/ bies.201800007
Saenz DT, Fiskus W, Manshouri T, et al. BET protein bro-modomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells. Leuke-mia. 2017; 31(3): 678-687. doi: 10.1038/leu.2016.260
Dawson MA, Prinjha RK, Dittmann A, et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011; 478(7370): 529-533.
Lockwood WW, Zejnullahu K, Bradner JE, Varmus H. Sensi-tivity of human lung adenocarcinoma cell lines to targeted inhibi-tion of BET epigenetic signaling proteins. Proc Natl Acad Sci U S A. 2012; 109(47): 19408-19413. doi: 10.1073/pnas.1216363109
Bid HK, Kerk S. BET bromodomain inhibitor (JQ1) and tumor angiogenesis. Oncoscience. 2016; 3(11-12): 316-317. doi: 10.18632/oncoscience.326
Bid HK, Phelps DA, Xaio L, et al. The bromodomain BET inhibitor JQ1 suppresses tumor angiogenesis in models of child-hood sarcoma. Mol Cancer Ther. 2016; 15(5): 1018-1028. doi: 10.1158/1535-7163.MCT-15-0567
Magistri M, Velmeshev D, Makhmutova M, et al. The BET-bromodomain inhibitor JQ1 reduces inflammation and tau phos-phorylation at Ser396 in the brain of the 3xTg model of alzheim-er’s disease. Curr Alzheimer Res. 2016; 13(9): 985-995.
Eskandarpour M, Alexander R, Adamson P, Calder VL. Phar-macological inhibition of bromodomain proteins suppresses retinal inflammatory disease and downregulates retinal Th17 cells. J Immunol. 2017; 198(3): 1093-1103. doi: 10.4049/jimmu-nol.1600735
Cheung K, Lu G, Sharma R, et al. BET N-terminal bromo-domain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proc Natl Acad Sci U S A. 2017; 114(11): 2952-2957. doi: 10.1073/pnas.1615601114
Manara MC, Valente S, Cristalli C, et al. A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in os-teosarcoma therapy. Mol Cancer Ther. 2018; 17(9): 1881-1892. doi: 10.1158/1535-7163.MCT-17-0818
Yang J, Tian X, Yang J, et al. 5-Aza-2’-deoxycytidine, a DNA methylation inhibitor, induces cytotoxicity, cell cycle dynamics and alters expression of DNA methyltransferase 1 and 3A in mouse hippocampus-derived neuronal HT22 cells. J Toxicol Environ Health A. 2017; 80(22): 1222-1229. doi: 10.1080/15287394.2017.1367143
Andrade AF, Borges KS, Suazo VK, et al. The DNA meth-yltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medul-loblastoma. Invest New Drugs. 2017; 35(1): 26-36. doi: 10.1007/ s10637-016-0401-4
Shilpi A, Parbin S, Sengupta D, et al. Mechanisms of DNA methyltransferase-inhibitor interactions: Procyanidin B2 shows new promise for therapeutic intervention of cancer. Chem Biol Interact. 2015; 233: 122-138. doi: 10.1016/j.cbi.2015.03.022
Konac E, Varol N, Yilmaz A, Menevse S, Sozen S. DNA methyltransferase inhibitor-mediated apoptosis in the Wnt/ beta-catenin signal pathway in a renal cell carcinoma cell line. Exp Biol Med (Maywood). 2013; 238(9): 1009-1016. doi: 10.1177/1535370213498984
Yang QW, Liu S, Tian Y, et al. Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma. Cancer Res. 2003; 63(19): 6299-6310.
Griffiths EA, Gore SD. DNA methyltransferase and his-tone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin Hematol. 2008; 45(1): 23-30. doi: 10.1053/j. seminhematol.2007.11.007
Singer BD, Mock JR, Aggarwal NR, et al. Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation. Am J Respir Cell Mol Biol. 2015; 52(5): 641-652. doi: 10.1165/rcmb.2014-0327OC
Wang J, Hodes GE, Zhang H, et al. Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nat Commun. 2018; 9(1): 477. doi: 10.1038/s41467- 017-02794-5
Adams KR, Chauhan S, Patel DB, et al. Ubiquitin Conjuga-tion Probed by Inflammation in Myeloid-Derived Suppressor Cell Extracellular Vesicles. J Proteome Res. 2018; 17(1): 315-324. doi: 22 Yang Q, et al 10.1021/acs.jproteome.7b00585
Hammitzsch A, Tallant C, Fedorov O, et al. CBP30, a selec-tive CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. Proc Natl Acad Sci U S A. 2015; 112(34): 10768-10773. doi: 10.1073/pnas.1501956112
Thangavel J, Samanta S, Rajasingh S, et al. Epigenetic modi-fiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. J Cell Sci. 2015; 128(16): 3094-3105. doi: 10.1242/jcs.170258
Shen J, Wu S, Guo W, et al. Epigenetic regulation of pro-inflammatory cytokine genes in lipopolysaccharide -stimulated peripheral blood mononuclear cells from broilers. Immunobiology. 2017; 222(2): 308-315. doi: 10.1016/j.imbio.2016.09.009
Grabiec AM, Krausz S, de Jager W, et al. Histone deacety-lase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. J Immunol. 2010; 184(5): 2718-2728. doi: 10.4049/jimmunol.0901467
Joosten LA, Leoni F, Meghji S, Mascagni P. Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis. Mol Med. 2011; 17(5-6): 391-396. doi: 10.2119/molmed.2011.00058
Leoni F, Fossati G, Lewis EC, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cyto-kines in vitro and systemic inflammation in vivo. Mol Med. 2005; 11(1-12): 1-15. doi: 10.2119/2006-00005.Dinarello
Leoni F, Zaliani A, Bertolini G, et al. The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhib-its antiinflammatory properties via suppression of cytokines. Proc Natl Acad Sci U S A. 2002; 99(5): 2995-3000. doi: 10.1073/ pnas.052702999
Gillespie J, Savic S, Wong C, et al. Histone deacetylases are dys-regulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by periph-eral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Rheum. 2012; 64(2): 418-422. doi: 10.1002/art.33382
Saouaf SJ, Li B, Zhang G, et al. Deacetylase inhibition increas-es regulatory T cell function and decreases incidence and severity of collagen-induced arthritis. Exp Mol Pathol. 2009; 87(2): 99-104. doi: 10.1016/j.yexmp.2009.06.003
Marquardt JU, Gomez-Quiroz L, Arreguin Camacho LO, et al. Curcumin effectively inhibits oncogenic NF-kappaB signaling and restrains stemness features in liver cancer. J Hepatol. 2015; 63(3): 661-669. doi: 10.1016/j.jhep.2015.04.018
Chen Y, Shu W, Chen W, et al. Curcumin, both histone deacet-ylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells. Basic Clin Systematic Review | Volume 4 | Number 1| Pharmacol Toxicol. 2007; 101(6): 427-433. doi: 10.1111/j.1742- 7843.2007.00142.x
Wei ZQ, Zhang YH, Ke CZ, et al. Curcumin inhibits hepati-tis B virus infection by down-regulating cccDNA-bound histone acetylation. World J Gastroenterol. 2017; 23(34): 6252-6260. doi: 10.3748/wjg.v23.i34.6252
Kadiyala CS, Zheng L, Du Y, et al. Acetylation of retinal his-tones in diabetes increases inflammatory proteins: effects of mi-nocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC). J Biol Chem. 2012; 287(31): 25869-25880. doi: 10.1074/jbc.M112.375204
Busbee PB, Nagarkatti M, Nagarkatti PS. Natural indoles, in-dole-3-carbinol and 3,3’-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation in-volving HDAC expression. Toxicol Appl Pharmacol. 2014; 274(1): 7-16. doi: 10.1016/j.taap.2013.10.022
Nishida K, Komiyama T, Miyazawa S, et al. Histone deacety-lase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21(WAF1/Cip1) ex-pression. Arthritis Rheum. 2004; 50(10): 3365-3376. doi: 10.1002/ art.20709
Zhang ZY, Schluesener HJ. HDAC inhibitor MS-275 attenu-ates the inflammatory reaction in rat experimental autoimmune prostatitis. Prostate. 2012; 72(1): 90-99. doi: 10.1002/pros.21410
Hogh Kolbaek Kjaer AS, Brinkmann CR, Dinarello CA, et al. The histone deacetylase inhibitor panobinostat lowers biomarkers of cardiovascular risk and inflammation in HIV patients. AIDS. 2015; 29(10): 1195-1200. doi: 10.1097/QAD.0000000000000678
Qu X, Proll M, Neuhoff C, et al. Sulforaphane epigenetically Submit your article to this journal | https://openventio.org/submit-manuscript/ Systematic Review | Volume 4 | Number 1| Yang Q, et al regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide. PLoS One. 2015; 10(3): e0121574. doi: 10.1371/journal.pone.0121574
Orecchia A, Scarponi C, Di Felice F, et al. Sirtinol treatment reduces inflammation in human dermal microvascular endothe-lial cells. PLoS One. 2011; 6(9): e24307. doi: 10.1371/journal. pone.0024307
Lugrin J, Ciarlo E, Santos A, et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Bio-chim Biophys Acta. 2013; 1833(6): 1498-1510. doi: 10.1016/j.bbam-cr.2013.03.004
Cantley MD, Fairlie DP, Bartold PM, et al. Inhibiting his-tone deacetylase 1 suppresses both inflammation and bone loss in arthritis. Rheumatology (Oxford). 2015; 54(9): 1713-1723. doi: 10.1093/rheumatology/kev022
Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013; 72(3): 178-185. doi: 10.1097/ NEN.0b013e318283114a
Zhang ZY, Zhang Z, Schluesener HJ. MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat ex-perimental autoimmune neuritis. Neuroscience. 2010; 169(1): 370- 377. doi: 10.1016/j.neuroscience.2010.04.074
Vishwakarma S, Iyer LR, Muley M, et al. Tubastatin, a selec-tive histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects. Int Immunopharmacol. 2013; 16(1): 72-78. doi: 10.1016/j.intimp.2013.03.016
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in Cancer Studies and Molecular Medicine (CSMM) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.
