The Emerging Role of p27 in Development of Diseases

Authors

  • Qiwei Yang
  • Ayman Al-Hendy

Abstract

The cell cycle regulation and tumor suppressor p27 encoded by CDKN1B plays a key role in many cellular events.1-3 p27 is a member of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors, which functions to negatively regulate cell cycle progression at the G1/S boundary in response to antiproliferative stimuli. In addition, numerous p27 functions, not related to CDK inhibition, have been described. For instance, cytosolic p27 plays a role in the regulation of cytoskeleton assembly/disassembly, therefore, regulates the cell morphology and movement. In addition, p27 is involved in apoptosis and autophagy modulation.

Downloads

Published

2018-05-09

How to Cite

Qiwei Yang, & Ayman Al-Hendy. (2018). The Emerging Role of p27 in Development of Diseases. Cancer Studies and Molecular Medicine , 4(1), 24–26. Retrieved from https://openventio.us/index.php/CSMM/article/view/1464

Issue

Vol. 4 No. 1 (2018): Volume 4 Issue 1 2018

Section

Articles

License

All content published in Cancer Studies and Molecular Medicine (CSMM) is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows anyone to copy, distribute, transmit, and adapt the work — including for commercial purposes — provided appropriate credit is given to the original author(s) and source.